The Prediction of Calpain Cleavage Sites with the mRMR and IFS Approaches
المؤلفون المشاركون
Ma, Zhiqiang
Wang, Jia-Nan
Zhang, Wen-yi
Xu, Xin
Jia, Longjia
Luo, Na
المصدر
Mathematical Problems in Engineering
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-08
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Calpains are an important family of the Ca2+-dependent cysteine proteases which catalyze the limited proteolysis of many specific substrates.
Calpains play crucial roles in basic physiological and pathological processes, and identification of the calpain cleavage sites may facilitate the understanding of the molecular mechanisms and biological function.
But traditional experiment approaches to predict the sites are accurate, and are always labor-intensive and time-consuming.
Thus, it is common to see that computational methods receive increasing attention due to their convenience and fast speed in recent years.
In this study, we develop a new predictor based on the support vector machine (SVM) with the maximum relevance minimum redundancy (mRMR) method followed by incremental feature selection (IFS).
And we concern the feature of physicochemical/biochemical properties, sequence conservation, residual disorder, secondary structure, and solvent accessibility to represent the calpain cleavage sites.
Experimental results show that the performance of our predictor is better than several other state-of- the-art predictors, whose average prediction accuracy is 79.49%, sensitivity is 62.31%, and specificity is 88.12%.
Since user-friendly and publicly accessible web servers represent the future direction for developing practically more useful predictors, here we have provided a web-server for the method presented in this paper.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Wen-yi& Xu, Xin& Jia, Longjia& Ma, Zhiqiang& Luo, Na& Wang, Jia-Nan. 2013. The Prediction of Calpain Cleavage Sites with the mRMR and IFS Approaches. Mathematical Problems in Engineering،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1032417
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Wen-yi…[et al.]. The Prediction of Calpain Cleavage Sites with the mRMR and IFS Approaches. Mathematical Problems in Engineering No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1032417
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Wen-yi& Xu, Xin& Jia, Longjia& Ma, Zhiqiang& Luo, Na& Wang, Jia-Nan. The Prediction of Calpain Cleavage Sites with the mRMR and IFS Approaches. Mathematical Problems in Engineering. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1032417
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1032417
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر