Roquefort Cheese Proteins Inhibit Chlamydia pneumoniae Propagation and LPS-Induced Leukocyte Migration

المؤلفون المشاركون

Zigangirova, Naylia A.
Bashmakov, Yuriy K.
Kobets, Natalie V.
Tsibezov, Valery
Kapotina, Lydia N.
Fedina, Elena D.
Petyaev, Ivan M.

المصدر

The Scientific World Journal

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-04-28

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب

الملخص EN

Inflammation in atherosclerosis, which could be associated with some subclinical infections such as C.

pneumoniae, is one of the key factors responsible for the development of clinical complications of this disease.

We report that a proprietary protein extract isolated from Roquefort cheese inhibits the propagation of C.

pneumoniae in a human HL cell line in a dose-dependent manner, as revealed by the immunofluorescence analysis.

These changes were accompanied by a significant reduction in the infective progeny formation over the protein extract range of 0.12–0.5 μg/mL.

Moreover, short term feeding of mice with Roquefort cheese (twice, 10 mg per mouse with an interval of 24 hours) led to the inhibition of the migration of peritoneal leukocytes caused by intraperitoneal injection of E.

coli lipopolysaccharide.

These changes were complemented by a reduction in neutrophil count and a relative increase in peritoneal macrophages, suggesting that ingestion of Roquefort could promote regenerative processes at the site of inflammation.

The ability of this protein to inhibit propagation of Chlamydia infection, as well as the anti-inflammatory and proregenerative effects of Roquefort itself, may contribute to the low prevalence of cardiovascular mortality in France where consumption of fungal fermented cheeses is the highest in the world.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Petyaev, Ivan M.& Zigangirova, Naylia A.& Kobets, Natalie V.& Tsibezov, Valery& Kapotina, Lydia N.& Fedina, Elena D.…[et al.]. 2013. Roquefort Cheese Proteins Inhibit Chlamydia pneumoniae Propagation and LPS-Induced Leukocyte Migration. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1032568

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Petyaev, Ivan M.…[et al.]. Roquefort Cheese Proteins Inhibit Chlamydia pneumoniae Propagation and LPS-Induced Leukocyte Migration. The Scientific World Journal No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1032568

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Petyaev, Ivan M.& Zigangirova, Naylia A.& Kobets, Natalie V.& Tsibezov, Valery& Kapotina, Lydia N.& Fedina, Elena D.…[et al.]. Roquefort Cheese Proteins Inhibit Chlamydia pneumoniae Propagation and LPS-Induced Leukocyte Migration. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1032568

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1032568