Neoplastic Meningitis: How MRI and CSF Cytology Are Influenced by CSF Cell Count and Tumor Type
المؤلفون المشاركون
Prömmel, P.
Pilgram-Pastor, S.
Sitter, H.
Buhk, J.-H.
Strik, H.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-19
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Background.
Although CSF cytology and MRI are standard methods to diagnose neoplastic meningitis (NM), this complication of neoplastic disease remains difficult to detect.
We therefore reevaluated the sensitivity of gadolinium (GD)-enhanced MRI and cerebrospinal-fluid (CSF)-cytology and the relevance of tumor type and CSF cell count.
Methods.
We retrospectively identified 111 cases of NM diagnosed in our CSF laboratory since 1990 with complete documentation of both MRI and CSF cytology.
37 had haematological and 74 solid neoplasms.
CSF cell counts were increased in 74 and normal in 37 patients.
Results.
In hematological neoplasms, MRI was positive in 49% and CSF cytology in 97%.
In solid tumors, the sensitivity of MRI was 80% and of cytology 78%.
With normal CSF cell counts, MRI was positive in 59% (50% hematological, 72% solid malignancies) and CSF cytology in 76% (92% in hematological, 68% in solid neoplasms).
In cases of elevated cell counts, the sensitivity of MRI was 72% (50% for hematological, 83% for solid malignancies) and of CSF cytology 91% (100% for haematological and 85% for solid neoplasms).
91% of cytologically positive cases were diagnosed at first and another 7% at second lumbar puncture.
Routine protein analyses had a low sensitivity in detecting NM.
Conclusions.
The high overall sensitivity of MRI was only confirmed for NM from solid tumors and for elevated CSF cell counts.
With normal cell counts and haematological neoplasms, CSF-cytology was superior to MRI.
None of the analysed routine CSF proteins had an acceptable sensitivity and specificity in detecting leptomeningeal disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Prömmel, P.& Pilgram-Pastor, S.& Sitter, H.& Buhk, J.-H.& Strik, H.. 2013. Neoplastic Meningitis: How MRI and CSF Cytology Are Influenced by CSF Cell Count and Tumor Type. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1032697
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Prömmel, P.…[et al.]. Neoplastic Meningitis: How MRI and CSF Cytology Are Influenced by CSF Cell Count and Tumor Type. The Scientific World Journal No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1032697
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Prömmel, P.& Pilgram-Pastor, S.& Sitter, H.& Buhk, J.-H.& Strik, H.. Neoplastic Meningitis: How MRI and CSF Cytology Are Influenced by CSF Cell Count and Tumor Type. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1032697
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1032697
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر