Targeting the Vasculature of Colorectal Carcinoma with a Fused Protein of (RGD)3-tTF
المؤلفون المشاركون
Zhao, Yilin
Huang, Zheng-jie
Luo, Wei-yuan
You, Jun
Li, Shui-wen
Yi, Wen-cheng
Wang, Sheng-yu
Yan, Jiang-hua
Luo, Qi
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-18
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Purpose.
Truncated tissue factor (tTF) fusion protein targeting tumor vasculature can induce tumor vascular thrombosis and necrosis.
Here, we generated (RGD)3-tTF in which three arginine-glycine-aspartic (RGD) targeting integrin αvβ3 and tTF induce blood coagulation in tumor vessels.
Methods.
The bioactivities of (RGD)3-tTF including coagulation activity, FX activation, and binding with integrin αvβ3 were performed.
The fluorescent labeled (RGD)3-tTF was intravenously injected into tumor-bearing mice and traced in vivo.
The tumor growth, volume, blood vessel thrombosis, tumor necrosis, and survival time of mice treated with (RGD)3-tTF were evaluated.
Results.
The clotting time and FX activation of (RGD)3-tTF were similar to that of TF (P>0.05) but different with that of RGD (P<0.05).
(RGD)3-tTF presented a higher binding with αvβ3 than that of RGD and TF at the concentration of 0.2 μmol/L (P<0.05).
(RGD)3-tTF could specifically assemble in tumor and be effective in reducing tumor growth by selectively inducing tumor blood vessels thrombosis and tumor necrosis which were absent in mice treated with RGD or TF.
The survival time of mice treated with (RGD)3-tTF was higher than that of mice treated with TF or RGD (P<0.05).
Conclusion.
(RGD)3-tTF may be a promising strategy for the treatment of colorectal cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Zheng-jie& Zhao, Yilin& Luo, Wei-yuan& You, Jun& Li, Shui-wen& Yi, Wen-cheng…[et al.]. 2013. Targeting the Vasculature of Colorectal Carcinoma with a Fused Protein of (RGD)3-tTF. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1033155
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Zheng-jie…[et al.]. Targeting the Vasculature of Colorectal Carcinoma with a Fused Protein of (RGD)3-tTF. The Scientific World Journal No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1033155
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Zheng-jie& Zhao, Yilin& Luo, Wei-yuan& You, Jun& Li, Shui-wen& Yi, Wen-cheng…[et al.]. Targeting the Vasculature of Colorectal Carcinoma with a Fused Protein of (RGD)3-tTF. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1033155
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1033155
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر