The Ethanol Extract of the Inner Bark of Caesalpinia pyramidalis (Tul.) Reduces Urinary Bladder Damage during Cyclophosphamide-Induced Cystitis in Rats
المؤلفون المشاركون
Moraes, Janaína P.
Pereira, Denyson S.
Matos, Alexandre S.
Santana, Danielle G.
Santos, Cliomar A.
Estevam, Charles S.
Fakhouri, Ricardo
Camargo, Enilton A.
Lucca Júnior, Waldecy De
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Hemorrhagic cystitis (HC) is a common side effect of cyclophosphamide therapy, which deserves new therapeutic strategies, such as those based on natural products.
The ethanol extract of the inner bark of Caesalpinia pyramidalis (Tul.) (EECp) possesses anti-inflammatory, antinociceptive, and antioxidant activities as previously showed by our group.
We have investigated the effect of EECp on the cyclophosphamide-induced HC.
Cystitis was induced in male Wistar rats by the injection of cyclophosphamide.
These animals were pretreated with EECp (100–400 mg/kg), vehicle, or mesna.
Myeloperoxidase activity and malondialdehyde formation were measured in urinary bladder and other tissues.
Bladder edema and histopathological alterations and serum nitric oxide metabolites concentration NOx- were also evaluated.
Treatment with EECp (100–400 mg/kg) or mesna impaired the increase of myeloperoxidase activity in urinary bladder and the serum NOx- induced by cyclophosphamide but did not reduce edema in this tissue, as did mesna.
Total histological score was reduced by EECp (100 mg/kg).
Lung myeloperoxidase activity, which was increased by cyclophosphamide, was decreased significantly by EECp (400 mg/kg).
EECp also diminished the malondialdehyde formation in bladder, lung, and spleen, although these parameters were not affected by cyclophosphamide.
These results indicate that EECp reduced urinary bladder damage during cyclophosphamide-induced HC in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moraes, Janaína P.& Pereira, Denyson S.& Matos, Alexandre S.& Santana, Danielle G.& Santos, Cliomar A.& Estevam, Charles S.…[et al.]. 2013. The Ethanol Extract of the Inner Bark of Caesalpinia pyramidalis (Tul.) Reduces Urinary Bladder Damage during Cyclophosphamide-Induced Cystitis in Rats. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1033204
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moraes, Janaína P.…[et al.]. The Ethanol Extract of the Inner Bark of Caesalpinia pyramidalis (Tul.) Reduces Urinary Bladder Damage during Cyclophosphamide-Induced Cystitis in Rats. The Scientific World Journal No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1033204
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moraes, Janaína P.& Pereira, Denyson S.& Matos, Alexandre S.& Santana, Danielle G.& Santos, Cliomar A.& Estevam, Charles S.…[et al.]. The Ethanol Extract of the Inner Bark of Caesalpinia pyramidalis (Tul.) Reduces Urinary Bladder Damage during Cyclophosphamide-Induced Cystitis in Rats. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1033204
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1033204
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر