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Identification of Biomarkers for Esophageal Squamous Cell Carcinoma Using Feature Selection and Decision Tree Methods
المؤلفون المشاركون
Tung, C.-W.
Chen, Yu-Kuei
Wu, Chun-Chieh
Chen, Wei-Chung
Li, Hsien-Pin
Chou, Shah-Hwa
Wu, I-Chen
Wu, Ming-Tsang
Wu, Deng-Chyang
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-12
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Esophageal squamous cell cancer (ESCC) is one of the most common fatal human cancers.
The identification of biomarkers for early detection could be a promising strategy to decrease mortality.
Previous studies utilized microarray techniques to identify more than one hundred genes; however, it is desirable to identify a small set of biomarkers for clinical use.
This study proposes a sequential forward feature selection algorithm to design decision tree models for discriminating ESCC from normal tissues.
Two potential biomarkers of RUVBL1 and CNIH were identified and validated based on two public available microarray datasets.
To test the discrimination ability of the two biomarkers, 17 pairs of expression profiles of ESCC and normal tissues from Taiwanese male patients were measured by using microarray techniques.
The classification accuracies of the two biomarkers in all three datasets were higher than 90%.
Interpretable decision tree models were constructed to analyze expression patterns of the two biomarkers.
RUVBL1 was consistently overexpressed in all three datasets, although we found inconsistent CNIH expression possibly affected by the diverse major risk factors for ESCC across different areas.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tung, C.-W.& Wu, Ming-Tsang& Chen, Yu-Kuei& Wu, Chun-Chieh& Chen, Wei-Chung& Li, Hsien-Pin…[et al.]. 2013. Identification of Biomarkers for Esophageal Squamous Cell Carcinoma Using Feature Selection and Decision Tree Methods. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1033298
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tung, C.-W.…[et al.]. Identification of Biomarkers for Esophageal Squamous Cell Carcinoma Using Feature Selection and Decision Tree Methods. The Scientific World Journal No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1033298
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tung, C.-W.& Wu, Ming-Tsang& Chen, Yu-Kuei& Wu, Chun-Chieh& Chen, Wei-Chung& Li, Hsien-Pin…[et al.]. Identification of Biomarkers for Esophageal Squamous Cell Carcinoma Using Feature Selection and Decision Tree Methods. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1033298
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1033298
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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