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Therapeutic Doses of Nonsteroidal Anti-Inflammatory Drugs Inhibit Osteosarcoma MG-63 Osteoblast-Like Cells Maturation, Viability, and Biomineralization Potential
المؤلفون المشاركون
García-Martínez, O.
De Luna-Bertos, E.
Guildford, A.
Santin, M.
Ramos-Torrecillas, J.
Ruiz, C.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-19
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used to reduce pain and inflammation.
However, their effect on bone metabolisms is not well known, and results in the literature are contradictory.
The present study focusses on the effect of dexketoprofen, ketorolac, metamizole, and acetylsalicylic acid, at therapeutic doses, on different biochemical and phenotypic pathways in human osteoblast-like cells.
Osteoblasts (MG-63 cell line) were incubated in culture medium with 1–10 μM of dexketoprofen, ketorolac, metamizole, and acetylsalicylic acid.
Flow cytometry was used to study antigenic profile and phagocytic activity.
The osteoblastic differentiation was evaluated by mineralization and synthesis of collagen fibers by microscopy and alkaline phosphatase activity (ALP) by spectrophotometric assay.
Short-term treatment with therapeutic doses of NSAIDs modulated differentiation, antigenic profile, and phagocyte activity of osteoblast-like cells.
The treatment reduced ALP synthesis and matrix mineralization.
However, nonsignificant differences were observed on collagen syntheses after treatments.
The percentage of CD54 expression was increased with all treatments.
CD80, CD86, and HLA-DR showed a decreased expression, which depended on NSAID and the dose applied.
The treatments also decreased phagocyte activity in this cellular population.
The results of this paper provide evidences that NSAIDs inhibit the osteoblast differentiation process thus reducing their ability to produce new bone mineralized extracellular matrix.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
De Luna-Bertos, E.& Ramos-Torrecillas, J.& García-Martínez, O.& Guildford, A.& Santin, M.& Ruiz, C.. 2013. Therapeutic Doses of Nonsteroidal Anti-Inflammatory Drugs Inhibit Osteosarcoma MG-63 Osteoblast-Like Cells Maturation, Viability, and Biomineralization Potential. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1033329
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
De Luna-Bertos, E.…[et al.]. Therapeutic Doses of Nonsteroidal Anti-Inflammatory Drugs Inhibit Osteosarcoma MG-63 Osteoblast-Like Cells Maturation, Viability, and Biomineralization Potential. The Scientific World Journal No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-1033329
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
De Luna-Bertos, E.& Ramos-Torrecillas, J.& García-Martínez, O.& Guildford, A.& Santin, M.& Ruiz, C.. Therapeutic Doses of Nonsteroidal Anti-Inflammatory Drugs Inhibit Osteosarcoma MG-63 Osteoblast-Like Cells Maturation, Viability, and Biomineralization Potential. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1033329
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1033329
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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