The Prevalence of Antinuclear Antibodies in Patients with Sarcoidosis
المؤلفون المشاركون
Sever, Fidan
Duran, Arzu
Sen, Nazime
Karaarslan, Ahmet
Yilmaz, Hatice
Kobak, Şenol
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-17
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Introduction.
Sarcoidosis, which is a chronic inflammatory granulomatous disease, can mimic different rheumatologic diseases including connective tissue diseases.
Antinuclear antibodies are the markers used for connective tissue diseases.
Aim.
To determine antinuclear antibody frequency and any possible correlation with clinical and laboratory data in sarcoidosis patients.
Material and Method.
Forty-two sarcoidosis patients, 45 rheumatoid arthritis patients, and 45 healthy volunteers who were followed up in rheumatology outpatient clinic were included in this study.
Demographic, clinical, serological, and radiological data of all patients were recorded.
Antinuclear antibodies were determined with indirect immunofluorescent method and 1/100 titration was accepted as positive.
The cases that were ANA positive were evaluated with immunoblot method.
Results.
Average age of the 42 patients (10 males) with sarcoidosis was 45.2 (20–70 years), and average disease duration was 3.5 years.
ANA positivity was detected in 12 (28.5%) patients with sarcoidosis (1/100 in 10 patients, 1/320 in two patients), in 19 of RA patients (42.2%), and in two of healthy volunteers in low titer ( P < 0.001 ).
In the subgroup analysis made by immunblot test, one patient had anticentromere antibody, one had anti-Ro antibody, one had anti-Scl-70 antibody, one had anti-dsDNA antibody, and eight patients were negative.
The two patients who had anticentromere and anti-Scl-70 antibodies had also Sjögren’s syndrome and scleroderma diagnosis, respectively.
Discussion.
The prevalence of ANA in patients with sarcoidosis was found to be significantly higher than healthy control group and lower than RA patients.
This result shows that ANA may have an important role in the pathogenesis of sarcoidosis and also could be important in revealing the overlap syndromes of sarcoidosis-connective tissue diseases.
Further studies with larger series are necessary in this subject.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kobak, Şenol& Yilmaz, Hatice& Sever, Fidan& Duran, Arzu& Sen, Nazime& Karaarslan, Ahmet. 2014. The Prevalence of Antinuclear Antibodies in Patients with Sarcoidosis. Autoimmune Diseases،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1034189
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kobak, Şenol…[et al.]. The Prevalence of Antinuclear Antibodies in Patients with Sarcoidosis. Autoimmune Diseases No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-1034189
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kobak, Şenol& Yilmaz, Hatice& Sever, Fidan& Duran, Arzu& Sen, Nazime& Karaarslan, Ahmet. The Prevalence of Antinuclear Antibodies in Patients with Sarcoidosis. Autoimmune Diseases. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1034189
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034189
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر