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Serum Leptin Levels in Treatment-Naive Patients with Clinically Isolated Syndrome or Relapsing-Remitting Multiple Sclerosis
المؤلفون المشاركون
Markianos, Manolis
Koutsis, Georgios
Evangelopoulos, Maria-Eleftheria
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-19
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Several studies have investigated leptin levels in patients with multiple sclerosis (MS) with somewhat conflicting results.
They have all focused on patients with established relapsing-remitting (RR) MS but have not specifically looked at patients with clinically isolated syndrome (CIS) suggestive of MS, in the early stages of disease.
In this study, serum leptin levels were measured in 89 treatment-naïve patients with CIS (53 patients) or RRMS (36 patients) and 73 controls searching for differences between the groups and for associations with several disease parameters.
The expected significant sexual dimorphism in leptin levels (higher levels in females) was observed in both MS patients and controls.
Increased leptin levels were found in female patients with RRMS compared to female controls ( P = .003 ) and female CIS patients ( P = .001 ).
Female CIS patients had comparable levels to controls.
Leptin levels correlated positively to disease duration, but not to EDSS, in female patients with RRMS.
The results of the present study do not indicate involvement of leptin in the early stages of MS.
Normal leptin levels in patients with CIS suggest that leptin does not have a pathogenic role.
The ratio leptin/BMI increases during disease course in female MS patients in a time-dependent and disability-independent manner.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Evangelopoulos, Maria-Eleftheria& Koutsis, Georgios& Markianos, Manolis. 2014. Serum Leptin Levels in Treatment-Naive Patients with Clinically Isolated Syndrome or Relapsing-Remitting Multiple Sclerosis. Autoimmune Diseases،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1034191
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Evangelopoulos, Maria-Eleftheria…[et al.]. Serum Leptin Levels in Treatment-Naive Patients with Clinically Isolated Syndrome or Relapsing-Remitting Multiple Sclerosis. Autoimmune Diseases No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1034191
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Evangelopoulos, Maria-Eleftheria& Koutsis, Georgios& Markianos, Manolis. Serum Leptin Levels in Treatment-Naive Patients with Clinically Isolated Syndrome or Relapsing-Remitting Multiple Sclerosis. Autoimmune Diseases. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1034191
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034191
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