Potential Cardiovascular Risk Protection of Bilirubin in End-Stage Renal Disease Patients under Hemodialysis
المؤلفون المشاركون
Sameiro-Faria, Maria
Bronze-da-Rocha, Elsa
Belo, Luís
Quintanilha, Alexandre
Ribeiro, Sandra
Nascimento, Henrique
Kohlova, Michaela
Miranda, Vasco
Rocha-Pereira, Petronila
Santos-Silva, Alice
Teixeira, Laetitia
Costa, Elísio
Reis, Flávio
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-09
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
We evaluated the potential cardiovascular risk protection of bilirubin in hemodialysis (HD) patients.
An enlarged set of studies were evaluated in 191 HD patients, including hematological study, lipid profile, iron metabolism, nutritional, inflammatory markers, and dialysis adequacy.
The TA duplication screening in the UDP-glucuronosyltransferase 1 A1 (UGT1A1) promoter region was also performed.
The UGT1A1 genotype frequencies in HD patients were 49.2%, 42.4%, and 8.4% for 6/6, 6/7, and 7/7 genotypes, respectively.
Although no difference was found in UGT1A1 genotype distribution between the three tertiles of bilirubin, significant differences were found with increasing bilirubin levels, namely, a decrease in platelet, leukocyte, and lymphocyte counts, transferrin, oxidized low-density lipoprotein (ox-LDL), ox-LDL/low-density lipoprotein cholesterol ratio, apolipoprotein (Apo) A, Apo B, and interleukin-6 serum levels and a significant increased concentration of hemoglobin, hematocrit, erythrocyte count, iron, transferrin saturation, Apo A/Apo B ratio, adiponectin, and paraoxonase 1 serum levels.
After adjustment for age these results remained significant.
Our data suggest that higher bilirubin levels are associated with beneficial effects in HD patients, by improving lipid profile and reducing the inflammatory grade, which might contribute to increase in iron availability.
These results suggest a potential cardiovascular risk protection of bilirubin in HD patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sameiro-Faria, Maria& Kohlova, Michaela& Ribeiro, Sandra& Rocha-Pereira, Petronila& Teixeira, Laetitia& Nascimento, Henrique…[et al.]. 2014. Potential Cardiovascular Risk Protection of Bilirubin in End-Stage Renal Disease Patients under Hemodialysis. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034394
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sameiro-Faria, Maria…[et al.]. Potential Cardiovascular Risk Protection of Bilirubin in End-Stage Renal Disease Patients under Hemodialysis. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1034394
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sameiro-Faria, Maria& Kohlova, Michaela& Ribeiro, Sandra& Rocha-Pereira, Petronila& Teixeira, Laetitia& Nascimento, Henrique…[et al.]. Potential Cardiovascular Risk Protection of Bilirubin in End-Stage Renal Disease Patients under Hemodialysis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034394
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034394
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر