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Lenalidomide Induces Immunomodulation in Chronic Lymphocytic Leukemia and Enhances Antitumor Immune Responses Mediated by NK and CD4 T Cells
المؤلفون المشاركون
González-Rodríguez, Ana Pilar
Payer, Angel R.
Acebes-Huerta, Andrea
Huergo-Zapico, Leticia
Fernandez-Guizan, Azahara
López-Soto, Alejandro
González, Segundo
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-17
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Lenalidomide is an immunomodulatory drug with therapeutic activity in chronic lymphocytic leukemia (CLL).
However, it has pleiotropic effects, and the mechanism of action responsible for its therapeutic activity has not been well defined yet.
Herein, we show that lenalidomide treatment does not have an effect on the proliferation of leukemia cells, but it increases the proliferation of B cells from healthy donors.
Lenalidomide did not exert a direct effect on the apoptosis of leukemia cells obtained from CLL patients, although it indirectly induced their apoptosis through the activation of nonmalignant immune cells.
Thus, lenalidomide markedly increased the proliferation of NK and CD4 T cells.
The effect of lenalidomide on NK cells was secondary to the induction of IL-2 production by CD4 T cells.
Accordingly, depletion of T cells or blockade of IL-2 activity completely abrogated the proliferation of NK cells.
Additionally, lenalidomide enhanced NK and NKT-like cell-mediated natural cytotoxicity against leukemia cells from CLL patients.
Lenalidomide also upregulated CD20 expression on leukemia cells and, accordingly, it had a synergistic effect with rituximab on promoting antibody-dependent cell-mediated cytotoxicity against primary leukemia cells.
Overall, these observations provide a support for combining lenalidomide with rituximab as a treatment in CLL.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Acebes-Huerta, Andrea& Huergo-Zapico, Leticia& González-Rodríguez, Ana Pilar& Fernandez-Guizan, Azahara& Payer, Angel R.& López-Soto, Alejandro…[et al.]. 2014. Lenalidomide Induces Immunomodulation in Chronic Lymphocytic Leukemia and Enhances Antitumor Immune Responses Mediated by NK and CD4 T Cells. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034414
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Acebes-Huerta, Andrea…[et al.]. Lenalidomide Induces Immunomodulation in Chronic Lymphocytic Leukemia and Enhances Antitumor Immune Responses Mediated by NK and CD4 T Cells. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1034414
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Acebes-Huerta, Andrea& Huergo-Zapico, Leticia& González-Rodríguez, Ana Pilar& Fernandez-Guizan, Azahara& Payer, Angel R.& López-Soto, Alejandro…[et al.]. Lenalidomide Induces Immunomodulation in Chronic Lymphocytic Leukemia and Enhances Antitumor Immune Responses Mediated by NK and CD4 T Cells. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034414
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034414
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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