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Yokukansan, a Traditional Japanese Medicine, Adjusts Glutamate Signaling in Cultured Keratinocytes
المؤلفون المشاركون
Yamaguchi, Takuji
Kobayashi, Hiroyuki
Wakabayashi, Maki
Hasegawa, Toshio
Funakushi, Naoko
Suto, Hajime
Ueki, Rie
Ikeda, Shigaku
Ogawa, Hideoki
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-16
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Glutamate plays an important role in skin barrier signaling.
In our previous study, Yokukansan (YKS) affected glutamate receptors in NC/Nga mice and was ameliorated in atopic dermatitis lesions.
The aim of this study was to assess the effect of YKS on skin and cultured human keratinocytes.
Glutamate concentrations in skin of YKS-treated and nontreated NC/Nga mice were measured.
Then, glutamate release from cultured keratinocytes was measured, and extracellular glutamate concentrations in YKS-stimulated cultured human keratinocytes were determined.
The mRNA expression levels of NMDA receptor 2D (NMDAR2D) and glutamate aspartate transporter (GLAST) were also determined in YKS-stimulated cultured keratinocytes.
The glutamate concentrations and dermatitis scores increased in conventional mice, whereas they decreased in YKS-treated mice.
Glutamate concentrations in cell supernatants of cultured keratinocytes increased proportionally to the cell density.
However, they decreased dose-dependently with YKS.
YKS stimulation increased NMDAR2D in a concentration-dependent manner.
Conversely, GLAST decreased in response to YKS.
Our findings indicate that YKS affects peripheral glutamate signaling in keratinocytes.
Glutamine is essential as a transmitter, and dermatitis lesions might produce and release excess glutamate.
This study suggests that, in keratinocytes, YKS controls extracellular glutamate concentrations, suppresses N-methyl-D-aspartate (NMDA) receptors, and activates glutamate transport.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wakabayashi, Maki& Hasegawa, Toshio& Yamaguchi, Takuji& Funakushi, Naoko& Suto, Hajime& Ueki, Rie…[et al.]. 2014. Yokukansan, a Traditional Japanese Medicine, Adjusts Glutamate Signaling in Cultured Keratinocytes. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034443
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wakabayashi, Maki…[et al.]. Yokukansan, a Traditional Japanese Medicine, Adjusts Glutamate Signaling in Cultured Keratinocytes. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1034443
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wakabayashi, Maki& Hasegawa, Toshio& Yamaguchi, Takuji& Funakushi, Naoko& Suto, Hajime& Ueki, Rie…[et al.]. Yokukansan, a Traditional Japanese Medicine, Adjusts Glutamate Signaling in Cultured Keratinocytes. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034443
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034443
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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