Imaging Mass Spectrometry by Matrix-Assisted Laser DesorptionIonization and Stress-Strain Measurements in Iontophoresis Transepithelial Corneal Collagen Cross-Linking
المؤلفون المشاركون
Azzolini, Claudio
Vinciguerra, Riccardo
Vinciguerra, Paolo
Mencucci, Rita
Spoerl, Eberhard
Camesasca, Fabrizio I.
Favuzza, Eleonora
Mastropasqua, Rodolfo
Romano, Vito
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-02
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Purpose.
To compare biomechanical effect, riboflavin penetration and distribution in transepithelial corneal collagen cross-linking with iontophoresis (I-CXL), with standard cross linking (S-CXL) and current transepithelial protocol (TE-CXL).
Materials and Methods.
The study was divided into two different sections, considering, respectively, rabbit and human cadaver corneas.
In both sections corneas were divided according to imbibition protocols and irradiation power.
Imaging mass spectrometry by matrix-assisted laser desorption/ionization (MALDI-IMS) and stress-strain measurements were used.
Forty-eight rabbit and twelve human cadaver corneas were evaluated.
Results.
MALDI-IMS showed a deep riboflavin penetration throughout the corneal layers with I-CXL, with a roughly lower concentration in the deepest layers when compared to S-CXL, whereas with TE-CXL penetration was considerably less.
In rabbits, there was a significant increase (by 71.9% and P=0.05) in corneal rigidity after I-CXL, when compared to controls.
In humans, corneal rigidity increase was not significantly different among the subgroups.
Conclusions.
In rabbits, I-CXL induced a significant increase in corneal stiffness as well as better riboflavin penetration when compared to controls and TE-CXL but not to S-CXL.
Stress-strain in human corneas did not show significant differences among techniques, possibly because of the small sample size of groups.
In conclusion, I-CXL could be a valid alternative to S-CXL for riboflavin delivery in CXL, preserving the epithelium.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vinciguerra, Paolo& Mencucci, Rita& Romano, Vito& Spoerl, Eberhard& Camesasca, Fabrizio I.& Favuzza, Eleonora…[et al.]. 2014. Imaging Mass Spectrometry by Matrix-Assisted Laser DesorptionIonization and Stress-Strain Measurements in Iontophoresis Transepithelial Corneal Collagen Cross-Linking. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1034452
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vinciguerra, Paolo…[et al.]. Imaging Mass Spectrometry by Matrix-Assisted Laser DesorptionIonization and Stress-Strain Measurements in Iontophoresis Transepithelial Corneal Collagen Cross-Linking. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1034452
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vinciguerra, Paolo& Mencucci, Rita& Romano, Vito& Spoerl, Eberhard& Camesasca, Fabrizio I.& Favuzza, Eleonora…[et al.]. Imaging Mass Spectrometry by Matrix-Assisted Laser DesorptionIonization and Stress-Strain Measurements in Iontophoresis Transepithelial Corneal Collagen Cross-Linking. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1034452
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034452
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر