Iron as the Key Modulator of Hepcidin Expression in Erythroid Antibody-Mediated Hypoplasia
المؤلفون المشاركون
Belo, Luís
Fernandes, João
Ribeiro, Sandra
Bronze-da-Rocha, E.
Rocha-Pereira, Petronila
Santos-Silva, Alice
Garrido, Patrícia
Costa, Elísio
Reis, Flávio
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-17
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Erythroid hypoplasia (EH) is a rare complication associated with recombinant human erythropoietin (rHuEPO) therapies, due to development of anti-rHuEPO antibodies; however, the underlying mechanisms remain poorly clarified.
Our aim was to manage a rat model of antibody-mediated EH induced by rHuEPO and study the impact on iron metabolism and erythropoiesis.
Wistar rats treated during 9 weeks with a high rHuEPO dose (200 IU) developed EH, as shown by anemia, reduced erythroblasts, reticulocytopenia, and plasmatic anti-rHuEPO antibodies.
Serum iron was increased and associated with mRNA overexpression of hepatic hepcidin and other iron regulatory mediators and downregulation of matriptase-2; overexpression of divalent metal transporter 1 and ferroportin was observed in duodenum and liver.
Decreased EPO expression was observed in kidney and liver, while EPO receptor was overexpressed in liver.
Endogenous EPO levels were normal, suggesting that anti-rHuEPO antibodies blunted EPO function.
Our results suggest that anti-rHuEPO antibodies inhibit erythropoiesis causing anemia.
This leads to a serum iron increase, which seems to stimulate hepcidin expression despite no evidence of inflammation, thus suggesting iron as the key modulator of hepcidin synthesis.
These findings might contribute to improving new therapeutic strategies against rHuEPO resistance and/or development of antibody-mediated EH in patients under rHuEPO therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fernandes, João& Garrido, Patrícia& Ribeiro, Sandra& Rocha-Pereira, Petronila& Bronze-da-Rocha, E.& Belo, Luís…[et al.]. 2014. Iron as the Key Modulator of Hepcidin Expression in Erythroid Antibody-Mediated Hypoplasia. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034460
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fernandes, João…[et al.]. Iron as the Key Modulator of Hepcidin Expression in Erythroid Antibody-Mediated Hypoplasia. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1034460
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fernandes, João& Garrido, Patrícia& Ribeiro, Sandra& Rocha-Pereira, Petronila& Bronze-da-Rocha, E.& Belo, Luís…[et al.]. Iron as the Key Modulator of Hepcidin Expression in Erythroid Antibody-Mediated Hypoplasia. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034460
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034460
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر