Diethylstilbestrol Exposure in Neonatal Mice Induces Changes in the Adulthood in the Immune Response to Taenia crassiceps without Modifications of Parasite Loads
المؤلفون المشاركون
Morales-Montor, Jorge
Camacho-Arroyo, Ignacio
Nava-Castro, Karen E.
Ortega-Hernando, Alejandra
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Industrial growth has increased the exposition to endocrine disruptor compounds (EDC’s), which are exogenous agents with agonist or antagonist action of endogenous steroid hormones that may affect the course of parasite infections.
We wanted to determine if the exposure to diethylstilbestrol (DES), an estrogen agonist, to both male and female mice affected the immune response and their susceptibility to T.
crassiceps cysticercosis.
In all infected groups, females showed higher parasite loads than males, and neonatal DES administration did not modify this pattern.
In the spleen, noninfected mice showed sex-related differences in the percentage of the CD8+ subpopulation, but DES decreased the percentage of CD3+, CD19+, and CD8+ subpopulations in infected mice.
In the mesenteric lymphatic node (MNL), DES showed a dimorphic effect in the percentage of CD19+ cells.
Regarding estrogen receptor alpha (ER-α) expression, DES treatment induced a reduction in the expression of this receptor in both noninfected female and male mice in the spleen, which was decreased only in males in CD3+ and CD8+ lymphocytes in MNL cell subpopulations.
Our study is the first one to demonstrate that DES neonatal treatment in male and female mice affects the immune cell percentage, without effect on the susceptibility to T.
crassiceps cysticercosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nava-Castro, Karen E.& Morales-Montor, Jorge& Ortega-Hernando, Alejandra& Camacho-Arroyo, Ignacio. 2014. Diethylstilbestrol Exposure in Neonatal Mice Induces Changes in the Adulthood in the Immune Response to Taenia crassiceps without Modifications of Parasite Loads. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034479
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nava-Castro, Karen E.…[et al.]. Diethylstilbestrol Exposure in Neonatal Mice Induces Changes in the Adulthood in the Immune Response to Taenia crassiceps without Modifications of Parasite Loads. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1034479
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nava-Castro, Karen E.& Morales-Montor, Jorge& Ortega-Hernando, Alejandra& Camacho-Arroyo, Ignacio. Diethylstilbestrol Exposure in Neonatal Mice Induces Changes in the Adulthood in the Immune Response to Taenia crassiceps without Modifications of Parasite Loads. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034479
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034479
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر