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Modifications in Lipid Levels Are Independent of Serum TNF-α in Rheumatoid Arthritis: Results of an Observational 24-Week Cohort Study Comparing Patients Receiving Etanercept Plus Methotrexate or Methotrexate as Monotherapy
المؤلفون المشاركون
Corona-Sanchez, Esther Guadalupe
Salazar-Paramo, Mario
Rodriguez-Jimenez, Norma Alejandra
Garcia-Gonzalez, Carlos E.
Ayala-Lopez, Karina Patricia
Trujillo-Hernandez, Benjamin
Aguilar-Chavez, Erika Anita
Vasquez-Jimenez, Jose Clemente
Vazquez-Del Mercado, Monica
Varon-Villalpando, Evangelina
Cota-Sanchez, Adolfo
Cardona-Muñoz, Ernesto German
Gonzalez-Lopez, Laura
Olivas-Flores, Eva Maria
Gamez-Nava, Jorge Ivan
Rocha-Muñoz, Alberto Daniel
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
To compare the modifications in lipids between patients with rheumatoid arthritis (RA) receiving etanercept plus methotrexate (ETA + MTX) versus methotrexate (MTX) and their relationship with serum levels of tumor necrosis factor-alpha (TNF-α).
Methods.
In an observational cohort study, we compared changes in lipid levels in patients receiving ETA + MTX versus MTX in RA.
These groups were assessed at baseline and at 4 and 24 weeks, measuring clinical outcomes, total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, and TNF-α.
Results.
Baseline values for lipid levels were similar in both groups.
HDL-C levels increased significantly only in the ETA + MTX group (from 45.5 to 50.0 mg/dL at 4 weeks, a 10.2% increase, P<0.001, and to 56.0 mg/dL at 24 weeks, a 25.1% increase, P<0.001), while other lipids underwent no significant changes.
ETA + MTX also exhibited a significant increase in TNF-α (44.8 pg/mL at baseline versus 281.4 pg/mL at 24 weeks, P<0.001).
The MTX group had no significant changes in lipids or TNF-α.
Significant differences in HDL-C between groups were observed at 24 weeks (P=0.04) and also in TNF-α (P=0.01).
Conclusion.
HDL-C levels increased significantly following treatment with ETA + MTX, without a relationship with decrease of TNF-α.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rodriguez-Jimenez, Norma Alejandra& Garcia-Gonzalez, Carlos E.& Ayala-Lopez, Karina Patricia& Trujillo-Hernandez, Benjamin& Aguilar-Chavez, Erika Anita& Rocha-Muñoz, Alberto Daniel…[et al.]. 2014. Modifications in Lipid Levels Are Independent of Serum TNF-α in Rheumatoid Arthritis: Results of an Observational 24-Week Cohort Study Comparing Patients Receiving Etanercept Plus Methotrexate or Methotrexate as Monotherapy. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034483
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rodriguez-Jimenez, Norma Alejandra…[et al.]. Modifications in Lipid Levels Are Independent of Serum TNF-α in Rheumatoid Arthritis: Results of an Observational 24-Week Cohort Study Comparing Patients Receiving Etanercept Plus Methotrexate or Methotrexate as Monotherapy. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1034483
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rodriguez-Jimenez, Norma Alejandra& Garcia-Gonzalez, Carlos E.& Ayala-Lopez, Karina Patricia& Trujillo-Hernandez, Benjamin& Aguilar-Chavez, Erika Anita& Rocha-Muñoz, Alberto Daniel…[et al.]. Modifications in Lipid Levels Are Independent of Serum TNF-α in Rheumatoid Arthritis: Results of an Observational 24-Week Cohort Study Comparing Patients Receiving Etanercept Plus Methotrexate or Methotrexate as Monotherapy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034483
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034483
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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