Modifications in Lipid Levels Are Independent of Serum TNF-α in Rheumatoid Arthritis: Results of an Observational 24-Week Cohort Study Comparing Patients Receiving Etanercept Plus Methotrexate or Methotrexate as Monotherapy
المؤلفون المشاركون
Corona-Sanchez, Esther Guadalupe
Salazar-Paramo, Mario
Rodriguez-Jimenez, Norma Alejandra
Garcia-Gonzalez, Carlos E.
Ayala-Lopez, Karina Patricia
Trujillo-Hernandez, Benjamin
Aguilar-Chavez, Erika Anita
Vasquez-Jimenez, Jose Clemente
Vazquez-Del Mercado, Monica
Varon-Villalpando, Evangelina
Cota-Sanchez, Adolfo
Cardona-Muñoz, Ernesto German
Gonzalez-Lopez, Laura
Olivas-Flores, Eva Maria
Gamez-Nava, Jorge Ivan
Rocha-Muñoz, Alberto Daniel
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
To compare the modifications in lipids between patients with rheumatoid arthritis (RA) receiving etanercept plus methotrexate (ETA + MTX) versus methotrexate (MTX) and their relationship with serum levels of tumor necrosis factor-alpha (TNF-α).
Methods.
In an observational cohort study, we compared changes in lipid levels in patients receiving ETA + MTX versus MTX in RA.
These groups were assessed at baseline and at 4 and 24 weeks, measuring clinical outcomes, total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, and TNF-α.
Results.
Baseline values for lipid levels were similar in both groups.
HDL-C levels increased significantly only in the ETA + MTX group (from 45.5 to 50.0 mg/dL at 4 weeks, a 10.2% increase, P<0.001, and to 56.0 mg/dL at 24 weeks, a 25.1% increase, P<0.001), while other lipids underwent no significant changes.
ETA + MTX also exhibited a significant increase in TNF-α (44.8 pg/mL at baseline versus 281.4 pg/mL at 24 weeks, P<0.001).
The MTX group had no significant changes in lipids or TNF-α.
Significant differences in HDL-C between groups were observed at 24 weeks (P=0.04) and also in TNF-α (P=0.01).
Conclusion.
HDL-C levels increased significantly following treatment with ETA + MTX, without a relationship with decrease of TNF-α.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rodriguez-Jimenez, Norma Alejandra& Garcia-Gonzalez, Carlos E.& Ayala-Lopez, Karina Patricia& Trujillo-Hernandez, Benjamin& Aguilar-Chavez, Erika Anita& Rocha-Muñoz, Alberto Daniel…[et al.]. 2014. Modifications in Lipid Levels Are Independent of Serum TNF-α in Rheumatoid Arthritis: Results of an Observational 24-Week Cohort Study Comparing Patients Receiving Etanercept Plus Methotrexate or Methotrexate as Monotherapy. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034483
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rodriguez-Jimenez, Norma Alejandra…[et al.]. Modifications in Lipid Levels Are Independent of Serum TNF-α in Rheumatoid Arthritis: Results of an Observational 24-Week Cohort Study Comparing Patients Receiving Etanercept Plus Methotrexate or Methotrexate as Monotherapy. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1034483
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rodriguez-Jimenez, Norma Alejandra& Garcia-Gonzalez, Carlos E.& Ayala-Lopez, Karina Patricia& Trujillo-Hernandez, Benjamin& Aguilar-Chavez, Erika Anita& Rocha-Muñoz, Alberto Daniel…[et al.]. Modifications in Lipid Levels Are Independent of Serum TNF-α in Rheumatoid Arthritis: Results of an Observational 24-Week Cohort Study Comparing Patients Receiving Etanercept Plus Methotrexate or Methotrexate as Monotherapy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034483
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034483
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر