A Higher Frequency of CD4+CXCR5+ T Follicular Helper Cells in Adult Patients with Minimal Change Disease
المؤلفون المشاركون
Jiang, Yanfang
Zhang, Nan
Shrestha, Amrita
Zhang, Li
Qu, Zhihui
Liu, Mingyuan
Zhang, Songling
Zhao, Pingwei
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-27
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
T follicular helper (TFH) cells are involved in the humoral immune responses.
This study is aimed at examining the frequencies of different subsets of CD4+CXCR5+ TFH cells in adult patients with minimal change disease (MCD).
Methods.
A total of 27 patients and 14 healthy controls (HC) were characterized for the levels of sera cytokines, inducible T-cell costimulator (ICOS), and programmed death 1 (PD-1) of positive TFH cells by flow cytometry.
The level of sera IL-21 was examined; 24 h urinary protein and eGFR were calculated.
The potential correlation between the frequency of different subsets of TFH cells and the values of clinical measures in MCD patients were analyzed.
Results.
The frequency of circulating CD4+CXCR5+, CD4+CXCR5+ICOS+, and CD4+CXCR5+PD-1+ TFH cells and the levels of sera IL-17A, IFN-γ, IL-2, IL-10, IL-4, and IL-21 were significantly higher in MCD patients ( P < 0.05 ) than that in the HC group.
Furthermore, the percentages of circulating CD4+CXCR5+ TFH cells were negatively correlated with the values of eGFR ( r = - 0.4849 , P < 0.05 ) and the percentages of CD4+CXCR5+PD-1+ TFH cells were correlated positively with the levels of serum IL-21 ( r = 0.6137 , P < 0.05 ) and 24 h urinary protein ( r = 0.1410 , P < 0.05 ) in those patients.
Also, the percentages of CD4+CXCR5+ICOS+ TFH cells were correlated positively with the levels of serum IL-21 ( r = 0.6201 , P < 0.05 ) and 24 h urinary protein ( r = 0.7519 , P < 0.05 ).
Following standard therapies, the percentages of circulating CD4+CXCR5+, CD4+CXCR5+PD-1+, and CD4+CXCR5+ICOS+ TFH cells and the levels of serum IL-21 were significantly reduced, but the levels of serum IL-4 and IL-10 were increased ( P < 0.05 ).
Conclusions.
A higher frequency of CD4+CXCR5+ TFH cells that existed in adult patients with MCD could be new target for intervention of MCD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Nan& Zhao, Pingwei& Shrestha, Amrita& Zhang, Li& Qu, Zhihui& Liu, Mingyuan…[et al.]. 2014. A Higher Frequency of CD4+CXCR5+ T Follicular Helper Cells in Adult Patients with Minimal Change Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1034581
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Nan…[et al.]. A Higher Frequency of CD4+CXCR5+ T Follicular Helper Cells in Adult Patients with Minimal Change Disease. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1034581
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Nan& Zhao, Pingwei& Shrestha, Amrita& Zhang, Li& Qu, Zhihui& Liu, Mingyuan…[et al.]. A Higher Frequency of CD4+CXCR5+ T Follicular Helper Cells in Adult Patients with Minimal Change Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1034581
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034581
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر