Effects and Tolerance of Silymarin (Milk Thistle) in Chronic Hepatitis C Virus Infection Patients: A Meta-Analysis of Randomized Controlled Trials
المؤلفون المشاركون
Yang, Zongguo
Lu, Yunfei
Xu, Qingnian
Chen, Xiaorong
Zhuang, Liping
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
This study aimed to evaluate the efficacy and safety of silymarin on chronic hepatitis C virus- (HCV-) infected patients.
Methods.
Randomized controlled trials (RCTs) of silymarin in chronic HCV-infected patients up to April 1, 2014 were systematically identified in PubMed, Ovid, Web of Science, and Cochrane Library databases.
Results.
A total of 222 and 167 patients in five RCTs were randomly treated with silymarin (or intravenous silibinin) and placebo, respectively.
Serum HCV RNA relatively decreased in patients treated with silymarin compared with those administered with placebo, but no significance was found ( P = 0.09 ).
Meta-analysis of patients orally treated with silymarin indicated that the changes of HCV RNA are similar in the two groups ( P = 0.19 ).
The effect on alanine aminotransferase (ALT) of oral silymarin is not different from that of placebo ( P = 0.45 ).
Improvements in quality-of-life (Short Form-36) in both silymarin and placebo recipients were impressive but relatively identical ( P = 0.09 ).
Conclusion.
Silymarin is well tolerated in chronic HCV-infected patients.
However, no evidence of salutary effects of oral silymarin has yet been reported based on intermediate endpoints (ALT and HCV RNA) in this population.
Moreover, intravenous administration of silymarin should be further studied.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Zongguo& Zhuang, Liping& Lu, Yunfei& Xu, Qingnian& Chen, Xiaorong. 2014. Effects and Tolerance of Silymarin (Milk Thistle) in Chronic Hepatitis C Virus Infection Patients: A Meta-Analysis of Randomized Controlled Trials. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034612
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Zongguo…[et al.]. Effects and Tolerance of Silymarin (Milk Thistle) in Chronic Hepatitis C Virus Infection Patients: A Meta-Analysis of Randomized Controlled Trials. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1034612
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Zongguo& Zhuang, Liping& Lu, Yunfei& Xu, Qingnian& Chen, Xiaorong. Effects and Tolerance of Silymarin (Milk Thistle) in Chronic Hepatitis C Virus Infection Patients: A Meta-Analysis of Randomized Controlled Trials. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034612
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034612
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر