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Tumor-Induced Osteomalacia: Increased Level of FGF-23 in a Patient with a Phosphaturic Mesenchymal Tumor at the Tibia Expressing Periostin
المؤلفون المشاركون
Hautmann, Anke H.
Schroeder, Josef
Hautmann, Matthias G.
Hoffstetter, Patrick
Girlich, Christiane
Huber, Elisabeth
Wild, Peter J.
Fleck, Martin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
In our case, a 45-year-old male patient had multiple fractures accompanied by hypophosphatemia.
FGF-23 levels were significantly increased, and total body magnetic resonance imaging (MRI) revealed a tumor mass located at the distal tibia leading to the diagnosis of tumor-induced osteomalacia (TIO).
After resection of the tumor, hypophosphatemia and the increased levels of FGF-23 normalized within a few days.
Subsequent microscopic examination and immunohistochemical analysis revealed a phosphaturic mesenchymal tumor mixed connective tissue variant (PMTMCT) showing a positive expression of somatostatin receptor 2A (SSTR2A), CD68, and Periostin.
Electron microscopy demonstrated a poorly differentiated mesenchymal tumor with a multifocal giant cell component and evidence of neurosecretory-granules.
However, the resected margins showed no tumor-free tissue, and therefore a subsequent postoperative radiotherapy was performed.
The patient is still in complete remission after 34 months.
Tumor resection of PMTMCTs is the therapy of choice.
Subsequent radiotherapy in case of incompletely resected tumors can be an important option to avoid recurrence or metastasis even though this occurs rarely.
The prognostic value of expression of Periostin has to be evaluated more precisely in a larger series of patients with TIO.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hautmann, Anke H.& Schroeder, Josef& Wild, Peter J.& Hautmann, Matthias G.& Huber, Elisabeth& Hoffstetter, Patrick…[et al.]. 2014. Tumor-Induced Osteomalacia: Increased Level of FGF-23 in a Patient with a Phosphaturic Mesenchymal Tumor at the Tibia Expressing Periostin. Case Reports in Endocrinology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034713
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hautmann, Anke H.…[et al.]. Tumor-Induced Osteomalacia: Increased Level of FGF-23 in a Patient with a Phosphaturic Mesenchymal Tumor at the Tibia Expressing Periostin. Case Reports in Endocrinology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1034713
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hautmann, Anke H.& Schroeder, Josef& Wild, Peter J.& Hautmann, Matthias G.& Huber, Elisabeth& Hoffstetter, Patrick…[et al.]. Tumor-Induced Osteomalacia: Increased Level of FGF-23 in a Patient with a Phosphaturic Mesenchymal Tumor at the Tibia Expressing Periostin. Case Reports in Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034713
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034713
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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