Postoperative Atypical Hemolytic Uremic Syndrome Associated with Complement C3 Mutation
المؤلفون المشاركون
Matsukuma, Eiji
Imamura, Atsushi
Iwata, Yusuke
Takeuchi, Takamasa
Yoshida, Yoko
Fujimura, Yoshihiro
Fan, Xinping
Kuwahara, Takashi
Miyata, T.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-06
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Atypical hemolytic uremic syndrome (aHUS) can be distinguished from typical or Shiga-like toxin-induced HUS.
The clinical outcome is unfavorable; up to 50% of affected patients progress to end-stage renal failure and 25% die during the acute phase.
Multiple conditions have been associated with aHUS, including infections, drugs, autoimmune conditions, transplantation, pregnancy, and metabolic conditions.
aHUS in the nontransplant postsurgical period, however, is rare.
An 8-month-old boy underwent surgical repair of tetralogy of Fallot.
Neurological disturbances, acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia developed 25 days later, and aHUS was diagnosed.
Further evaluation revealed that his complement factor H (CFH) level was normal and that anti-FH antibodies were not detected in his plasma.
Sequencing of his CFH, complement factor I, membrane cofactor protein, complement factor B, and thrombomodulin genes was normal.
His ADAMTS-13 (a disintegrin-like and metalloprotease with thrombospondin-1 repeats 13) activity was also normal.
However, he had a potentially causative mutation (R425C) in complement component C3.
Restriction fragment length polymorphism analysis revealed that his father and aunt also had this mutation; however, they had no symptoms of aHUS.
We herein report a case of aHUS that developed after cardiovascular surgery and was caused by a complement C3 mutation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Matsukuma, Eiji& Imamura, Atsushi& Iwata, Yusuke& Takeuchi, Takamasa& Yoshida, Yoko& Fujimura, Yoshihiro…[et al.]. 2014. Postoperative Atypical Hemolytic Uremic Syndrome Associated with Complement C3 Mutation. Case Reports in Nephrology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1034811
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Matsukuma, Eiji…[et al.]. Postoperative Atypical Hemolytic Uremic Syndrome Associated with Complement C3 Mutation. Case Reports in Nephrology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1034811
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Matsukuma, Eiji& Imamura, Atsushi& Iwata, Yusuke& Takeuchi, Takamasa& Yoshida, Yoko& Fujimura, Yoshihiro…[et al.]. Postoperative Atypical Hemolytic Uremic Syndrome Associated with Complement C3 Mutation. Case Reports in Nephrology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1034811
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034811
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر