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Fluvastatin Upregulates the α 1C Subunit of CaV1.2 Channel Expression in Vascular Smooth Muscle Cells via RhoA and ERKp38 MAPK Pathways
المؤلفون المشاركون
Ouyang, Qiufang
Han, Ying
Lin, Zhi-Hong
Xie, Hong
Xu, Chang-Sheng
Xie, Liang-Di
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Abnormal phenotypic switch of vascular smooth muscle cell (VSMC) is a hallmark of vascular disorders such as atherosclerosis and restenosis.
And this process has been related to remodeling of L-type calcium channel (LTCC).
We attempted to investigate whether fluvastatin has any effect on VSMC proliferation and LTCC α 1 C subunit ( L T C C α 1 C ) expression as well as the potential mechanisms involved.
The VSMCs proliferation was assayed by osteopontin immunofluorescent staining and [3H]-thymidine incorporation.
The cell cycle was detected by flow cytometric analysis.
The activity of RhoA was determined with pull-down assay.
MAPK activity and L T C C α 1 C expression were assessed by western blotting.
We demonstrated fluvastatin prevented the VSMCs dedifferentiating into a proliferative phenotype and induced cell cycle arrest in the G0/G1 phase in response to PDGF-BB stimulation.
Fluvastatin dose-dependently reversed the downregulation of L T C C α 1 C expression induced by PDGF-BB.
Inhibition of ROCK, ERK, or p38 MAPK activation largely enhanced the upregulation effect of fluvastatin ( P < 0.01 ) .
However, blockade of JNK pathway had no effect on L T C C α 1 C expression.
We concluded L T C C α 1 C was a VSMC contractile phenotype marker gene.
Fluvastatin upregulated L T C C α 1 C expression, at least in part, by inhibiting ROCK, ERK1/2, and p38 MAPK activation.
Fluvastatin may be a potential candidate for preventing or treating vascular diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ouyang, Qiufang& Han, Ying& Lin, Zhi-Hong& Xie, Hong& Xu, Chang-Sheng& Xie, Liang-Di. 2014. Fluvastatin Upregulates the α 1C Subunit of CaV1.2 Channel Expression in Vascular Smooth Muscle Cells via RhoA and ERKp38 MAPK Pathways. Disease Markers،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035051
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ouyang, Qiufang…[et al.]. Fluvastatin Upregulates the α 1C Subunit of CaV1.2 Channel Expression in Vascular Smooth Muscle Cells via RhoA and ERKp38 MAPK Pathways. Disease Markers No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035051
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ouyang, Qiufang& Han, Ying& Lin, Zhi-Hong& Xie, Hong& Xu, Chang-Sheng& Xie, Liang-Di. Fluvastatin Upregulates the α 1C Subunit of CaV1.2 Channel Expression in Vascular Smooth Muscle Cells via RhoA and ERKp38 MAPK Pathways. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035051
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035051
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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