![](/images/graphics-bg.png)
Bench to Bed Evidences for Pharmacokinetic and Pharmacodynamic Interactions Involving Oseltamivir and Chinese Medicine
المؤلفون المشاركون
Chan, Thomas Y. K.
Chang, Qi
Wo, Siukwan
Ngai, Karry L. K.
Wang, Xiaoan
Fok, Benny
Ngan, Teresa M.
Wong, Vivian T.
Lee, Vincent H. L.
Chan, Paul K. S.
Chow, Moses S. S.
Zuo, Zhong
Tomlinson, Brian
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-09
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Oseltamivir (OA), an ethyl ester prodrug of oseltamivir carboxylate (OC), is clinically used as a potent and selective inhibitor of neuraminidase.
Chinese medicines have been advocated to combine with conventional drug for avian influenza.
The current study aims to investigate the potential pharmacokinetic and pharmacodynamic interactions of a Chinese medicine formula, namely, Yin Qiao San and Sang Ju Yin (CMF1), commonly used for anti-influenza in combination with OA in both rat and human, and to reveal the underlined mechanisms.
It was found that although C max , AUC and urinary recovery of OC, as well as metabolic ratio ( AUC OC / AUC OA ), were significantly decreased in a dose-dependent manner following combination use of CMF1 and OA in rat studies ( P < 0.01 ), such coadministration in 14 healthy volunteers only resulted in a trend of minor decrease in the related parameters.
Further mechanistic studies found that although CMF1 could reduce absorption and metabolism of OA, it appears to enhance viral inhibition of OA ( P < 0.01 ).
In summary, although there was potential interaction between OA and CMF1 found in rat studies, its clinical impact was expected to be minimal.
The coadministration of OA and CMF1 at the clinical recommended dosages is, therefore, considered to be safe.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chang, Qi& Wo, Siukwan& Ngai, Karry L. K.& Wang, Xiaoan& Fok, Benny& Ngan, Teresa M.…[et al.]. 2014. Bench to Bed Evidences for Pharmacokinetic and Pharmacodynamic Interactions Involving Oseltamivir and Chinese Medicine. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035165
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chang, Qi…[et al.]. Bench to Bed Evidences for Pharmacokinetic and Pharmacodynamic Interactions Involving Oseltamivir and Chinese Medicine. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1035165
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chang, Qi& Wo, Siukwan& Ngai, Karry L. K.& Wang, Xiaoan& Fok, Benny& Ngan, Teresa M.…[et al.]. Bench to Bed Evidences for Pharmacokinetic and Pharmacodynamic Interactions Involving Oseltamivir and Chinese Medicine. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035165
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035165
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)