Ligand-Based and Structure-Based Investigation for Alzheimer’s Disease from Traditional Chinese Medicine
المؤلفون المشاركون
Lee, Wen-Yuan
Chen, Kuen-Bao
Chen, Calvin Yu-Chian
Liao, Kai Hsin
Lee, Cheng-Chun
Sun, Mao-Feng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-08
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Alzheimer’s disease is a neurodegenerative disease that was conventionally thought to be related to the sedimentation of beta-amyloids, but drugs designed according to this hypothesis have generally failed.
That FKBP52 can reduce the accumulation of tau proteins, and that Tacrolimus can reduce the pathological changes of tau proteins are new directions away from the long held amyloid-beta-centric concept.
Therefore, the screening of traditional Chinese medicine compounds for those with higher affinity towards FKBP52 than Tacrolimus may be a new direction for treating Alzheimer’s disease.
This study utilizes ligand-based and structure-based methods as the foundation.
By utilizing dock scores and the predicted pIC50 from SVM, MLR, and Bayesian Network, several TCM compounds were selected for further analysis of their protein-ligand interactions.
Daphnetoxin has higher affinity and complex structure stability than Tacrolimus; Lythrancine II exhibits the most identical trends in FKBP52 interactions as Tacrolimus, and 20-O-(2′E,4′E-decadienoyl)ingenol may be further modified at its hydrocarbon chain to promote interaction with FKBP52.
In addition, we observed the residue Tyr113 of FKBP52 may play a key role in protein-ligand interaction.
Our results indicate that Daphnetoxin, 20-O-(2′E,4′E-decadienoyl)ingenol, and Lythrancine II may be starting points for further modification as a new type of non-amyloid-beta-centric drug for Alzheimer’s disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liao, Kai Hsin& Chen, Kuen-Bao& Lee, Wen-Yuan& Sun, Mao-Feng& Lee, Cheng-Chun& Chen, Calvin Yu-Chian. 2014. Ligand-Based and Structure-Based Investigation for Alzheimer’s Disease from Traditional Chinese Medicine. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1035168
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liao, Kai Hsin…[et al.]. Ligand-Based and Structure-Based Investigation for Alzheimer’s Disease from Traditional Chinese Medicine. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1035168
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liao, Kai Hsin& Chen, Kuen-Bao& Lee, Wen-Yuan& Sun, Mao-Feng& Lee, Cheng-Chun& Chen, Calvin Yu-Chian. Ligand-Based and Structure-Based Investigation for Alzheimer’s Disease from Traditional Chinese Medicine. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1035168
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035168
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر