Ethanol Extract of Alismatis rhizome Inhibits Adipocyte Differentiation of OP9 Cells
المؤلفون المشاركون
Hwang, Jin-Ki
Oh, Hyun Cheol
Park, Yeon-Ju
Kim, Mi-Seong
Kim, Ha-Rim
Kim, Jeong-Mi
Kim, Hye-Jung
Yang, Sei-Hoon
Lee, Dong-Sung
Kim, Youn-Chul
Ryu, Do-Gon
Lee, Young-Rae
Kwon, Kang Beom
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-09
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The rhizome of Alisma orientale (Alismatis rhizome) has been used in Asia for promoting diuresis to eliminate dampness from the lower-jiao and to expel heat.
In this study, an ethanol extract of the rhizome of Alisma orientale (AOE) was prepared and its effects on adipocyte differentiation of OP9 cells were investigated.
Treatment with AOE in a differentiation medium for 5 days resulted in dose-dependent inhibition of lipid droplet formation in OP9 cells.
Furthermore, AOE significantly inhibited adipocyte differentiation by downregulating the expression of the master transcription factor of adipogenesis, peroxisome proliferation-activity receptor γ (PPARγ), and related genes, including CCAAT/enhancer binding protein β (C/EBPβ), fatty acid-binding protein (aP2), and fatty acid synthase (FAS).
AOE exerted its inhibitory effects primarily during the early adipogenesis stage (days 1-2), at which time it also exerted dose-dependent inhibition of the expression of C/EBPβ, a protein related to the inhibition of mitotic clonal expansion.
Additionally, AOE decreased the expression of autophagy-related proteins, including beclin 1, and the autophagy-related genes, (Atg) 7 and Atg12.
Our results indicate that AOE’s inhibitory effects on adipocyte differentiation of OP9 cells are mediated by reduced C/EBPβ expression, causing inhibition of mitotic clonal expansion and autophagy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, Yeon-Ju& Kim, Mi-Seong& Kim, Ha-Rim& Kim, Jeong-Mi& Hwang, Jin-Ki& Yang, Sei-Hoon…[et al.]. 2014. Ethanol Extract of Alismatis rhizome Inhibits Adipocyte Differentiation of OP9 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035189
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, Yeon-Ju…[et al.]. Ethanol Extract of Alismatis rhizome Inhibits Adipocyte Differentiation of OP9 Cells. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035189
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, Yeon-Ju& Kim, Mi-Seong& Kim, Ha-Rim& Kim, Jeong-Mi& Hwang, Jin-Ki& Yang, Sei-Hoon…[et al.]. Ethanol Extract of Alismatis rhizome Inhibits Adipocyte Differentiation of OP9 Cells. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035189
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035189
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر