Potential Protein Phosphatase 2A Agents from Traditional Chinese Medicine against Cancer
المؤلفون المشاركون
Chen, Calvin Yu-Chian
Chen, Calvin Yu-Chian
Chen, Kuan-Chung
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-29
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Protein phosphatase 2A (PP2A) is an important phosphatase which regulates various cellular processes, such as protein synthesis, cell growth, cellular signaling, apoptosis, metabolism, and stress responses.
It is a holoenzyme composed of the structural A and catalytic C subunits and a regulatory B subunit.
As an environmental toxin, okadaic acid, is a tumor promoter and binds to PP2A catalytic C subunit and the cancer-associated mutations in PP2A structural A subunit in human tumor tissue; PP2A may have tumor-suppressing function.
It is a potential drug target in the treatment of cancer.
In this study, we screen the TCM compounds in TCM Database@Taiwan to investigate the potent lead compounds as PP2A agent.
The results of docking simulation are optimized under dynamic conditions by MD simulations after virtual screening to validate the stability of H-bonds between PP2A-α protein and each ligand.
The top TCM candidates, trichosanatine and squamosamide, have potential binding affinities and interactions with key residues Arg89 and Arg214 in the docking simulation.
In addition, these interactions were stable under dynamic conditions.
Hence, we propose the TCM compounds, trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A-α protein.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Kuan-Chung& Chen, Calvin Yu-Chian& Chen, Calvin Yu-Chian. 2014. Potential Protein Phosphatase 2A Agents from Traditional Chinese Medicine against Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035197
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Kuan-Chung…[et al.]. Potential Protein Phosphatase 2A Agents from Traditional Chinese Medicine against Cancer. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035197
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Kuan-Chung& Chen, Calvin Yu-Chian& Chen, Calvin Yu-Chian. Potential Protein Phosphatase 2A Agents from Traditional Chinese Medicine against Cancer. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035197
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035197
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر