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In Vivo and In Vitro Antitumor Effects of Platycodin D, a Saponin Purified from Platycodi Radix on the H520 Lung Cancer Cell
المؤلفون المشاركون
Kim, Jong-Dae
Park, Jae Chan
Choi, Hae Yun
Shin, Yong Kook
Lee, Young-Joon
Ku, Sae-Kwang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-13
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Platycodin D is a major pharmacological constituent of Platycodi radix and has showed various pharmacological activities through oxidative stress defense mechanisms.
Here, possible antitumor, anticachexia, and immunomodulatory activities of platycodin D were observed on the H520 tumor cell-bearing athymic nude mice after confirming the in vitro cytotoxicity.
Platycodin D was orally administered at dose levels of 200, 100, and 50 mg/kg, once a day for 35 days from 15 days after implantation.
The results were compared with gemcitabine 160 mg/kg intraperitoneally treated mice (7-day intervals).
Platycodin D showed favorable cytotoxic effects on the H520 cells, and also dose-dependently decreased the tumor volumes and weights with increases of apoptotic cells (caspase-3 and PARP immunopositive cells), iNOS and TNF-α immunoreactivities, decreases of COX-2 immunoreactivities in tumor masses.
Platycodin D also showed dose-dependent immunostimulatory and anticachexia effects.
Gemcitabine showed favorable cytotoxity against H520 tumor cell and related in vivo antitumor effects but aggravated the cancer related cachexia and immunosuppress in H520 tumor cell-bearing athymic nude mice.
Taken together, it is considered that oral treatment of platycodin D has potent antitumor activities on H520 cells through direct cytotoxic effects, increases of apoptosis in tumor cells, and immunostimulatory effects and can be control cancer related cachexia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, Jae Chan& Lee, Young-Joon& Choi, Hae Yun& Shin, Yong Kook& Kim, Jong-Dae& Ku, Sae-Kwang. 2014. In Vivo and In Vitro Antitumor Effects of Platycodin D, a Saponin Purified from Platycodi Radix on the H520 Lung Cancer Cell. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1035216
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, Jae Chan…[et al.]. In Vivo and In Vitro Antitumor Effects of Platycodin D, a Saponin Purified from Platycodi Radix on the H520 Lung Cancer Cell. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-1035216
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, Jae Chan& Lee, Young-Joon& Choi, Hae Yun& Shin, Yong Kook& Kim, Jong-Dae& Ku, Sae-Kwang. In Vivo and In Vitro Antitumor Effects of Platycodin D, a Saponin Purified from Platycodi Radix on the H520 Lung Cancer Cell. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1035216
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035216
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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