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Crude Ethanol Extract of Pithecellobium ellipticum as a Potential Lipid-Lowering Treatment for Hypercholesterolaemia
المؤلفون المشاركون
Ting, Kang Nee
Khoo, Teng-Jin
Wong, Janet P.-C.
Wijaya, Sumi
Mustafa, Kamarul’Ain
Shipton, Fiona
Wiart, C.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-15
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
If left untreated, hypercholesterolaemia can lead to atherosclerosis, given time.
Plants from the Fabaceae family have shown the ability to significantly suppress atherosclerosis progression.
We selected four extracts from Pithecellobium ellipticum, from the Fabaceae family, to be screened in a 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) assay.
The ethanol extract, at a concentration of 500 μg/mL, exhibited superior inhibition properties over the other extracts by demonstrating 80.9% inhibition, while 0.223 μg/mL of pravastatin (control) showed 78.1% inhibition towards enzymatic activity.
These findings led to the fractionation of the ethanol extract using ethyl acetate : methanol (95 : 5), gradually increasing polarity and produced seven fractions (1A to 7A).
Fraction 7A at 150 μg/mL emerged as being the most promising bioactive fraction with 78.7% inhibition.
FRAP, beta carotene, and DPPH assays supported the findings from the ethanol extract as it exhibited good overall antioxidant activity.
The antioxidant properties have been said to reduce free radicals that are able to oxidize lipoproteins which are the cause of atherosclerosis.
Phytochemical screenings revealed the presence of terpenoid, steroid, flavonoid, and phenolic compounds as the responsible group of compound(s), working individually or synergistically, within the extract to prevent binding of HMG-CoA to HMG-CoA reductase.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wong, Janet P.-C.& Wijaya, Sumi& Ting, Kang Nee& Wiart, C.& Mustafa, Kamarul’Ain& Shipton, Fiona…[et al.]. 2014. Crude Ethanol Extract of Pithecellobium ellipticum as a Potential Lipid-Lowering Treatment for Hypercholesterolaemia. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035223
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wong, Janet P.-C.…[et al.]. Crude Ethanol Extract of Pithecellobium ellipticum as a Potential Lipid-Lowering Treatment for Hypercholesterolaemia. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035223
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wong, Janet P.-C.& Wijaya, Sumi& Ting, Kang Nee& Wiart, C.& Mustafa, Kamarul’Ain& Shipton, Fiona…[et al.]. Crude Ethanol Extract of Pithecellobium ellipticum as a Potential Lipid-Lowering Treatment for Hypercholesterolaemia. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035223
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035223
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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