Anti-Inflammatory Effects of the Bioactive Compound Ferulic Acid Contained in Oldenlandia diffusa on Collagen-Induced Arthritis in Rats
المؤلفون المشاركون
Wang, Yang
Zhu, Hao
Liang, Qing-Hua
Xiong, Xin-Gui
Chen, Jiang
Wu, Dan
Yang, Bo
Zhang, Yang
Zhang, Yong
Huang, Xi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objectives.
This study aimed to identify the active compounds in Oldenlandia diffusa (OD) decoction and the compounds absorbed into plasma, and to determine whether the absorbed compounds derived from OD exerted any anti-inflammatory effects in rats with collagen induced arthritis (CIA).
Methods.
The UPLC-PDA (Ultra Performance Liquid Chromatography Photo-Diode Array) method was applied to identify the active compounds both in the decoction and rat plasma.
The absorbable compound was administered to the CIA rats, and the effects were dynamically observed.
X-ray films of the joints and HE stain of synovial tissues were analyzed.
The levels of IL-1β and TNF-α in the rats from each group were measured by means of ELISA.
The absorbed compound in the plasma of CIA rats was identified as ferulic acid (FA), following OD decoction administration.
Two weeks after the administration of FA solution or OD decoction, the general conditions improved compared to the model group.
The anti-inflammatory effect of FA was inferior to that of the OD decoction ( P < 0.05 ), based on a comparison of IL-1β TNF-α levels.
FA from the OD decoction was absorbed into the body of CIA rats, where it elicited anti-inflammatory responses in rats with CIA.
Conclusions.
These results suggest that FA is the bioactive compound in OD decoction, and FA exerts its effects through anti-inflammatory pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhu, Hao& Liang, Qing-Hua& Xiong, Xin-Gui& Chen, Jiang& Wu, Dan& Wang, Yang…[et al.]. 2014. Anti-Inflammatory Effects of the Bioactive Compound Ferulic Acid Contained in Oldenlandia diffusa on Collagen-Induced Arthritis in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035285
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhu, Hao…[et al.]. Anti-Inflammatory Effects of the Bioactive Compound Ferulic Acid Contained in Oldenlandia diffusa on Collagen-Induced Arthritis in Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035285
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhu, Hao& Liang, Qing-Hua& Xiong, Xin-Gui& Chen, Jiang& Wu, Dan& Wang, Yang…[et al.]. Anti-Inflammatory Effects of the Bioactive Compound Ferulic Acid Contained in Oldenlandia diffusa on Collagen-Induced Arthritis in Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035285
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035285
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر