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Novel Antidepressant-Like Activity of Caffeic Acid Phenethyl Ester Is Mediated by Enhanced Glucocorticoid Receptor Function in the Hippocampus
المؤلفون المشاركون
Shim, Insop
Morita, Kyoji
Lee, Bo-ram
Moon, Won-Jin
Hong, Kwan-Su
Song, Yun Seon
Her, Song
Lee, Mi-Sook
Kwon, Seung-Hae
Kim, Young Han
Hahm, Dae-Hyun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Caffeic acid phenethyl ester (CAPE) is an active component of propolis that has a variety of potential pharmacological effects.
Although we previously demonstrated that propolis has antidepressant-like activity, the effect of CAPE on this activity remains unknown.
The present study assessed whether treatment with CAPE (5, 10, and 20 µmol/kg for 21 days) has an antidepressant-like effect in mice subjected to chronic unpredictable stress via tail suspension (TST) and forced swim (FST) tests.
CAPE administration induced behaviors consistent with an antidepressant effect, evidenced by decreased immobility in the TST and FST independent of any effect on serum corticosterone secretion.
Western blots, conducted subsequent to behavioral assessment, revealed that CAPE significantly decreased glucocorticoid receptor phosphorylation at S234 (pGR(S234)), resulting in an increased pGR(S220/S234) ratio.
We also observed negative correlations between pGR(S220)/(S234) and p38 mitogen-activated protein kinase (p38MAPK) phosphorylation, which was decreased by CAPE treatment.
These findings suggest that CAPE treatment exerts an antidepressant-like effect via downregulation of p38MAPK phosphorylation, thereby contributing to enhanced GR function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Mi-Sook& Kim, Young Han& Lee, Bo-ram& Kwon, Seung-Hae& Moon, Won-Jin& Hong, Kwan-Su…[et al.]. 2014. Novel Antidepressant-Like Activity of Caffeic Acid Phenethyl Ester Is Mediated by Enhanced Glucocorticoid Receptor Function in the Hippocampus. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035321
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Mi-Sook…[et al.]. Novel Antidepressant-Like Activity of Caffeic Acid Phenethyl Ester Is Mediated by Enhanced Glucocorticoid Receptor Function in the Hippocampus. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035321
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Mi-Sook& Kim, Young Han& Lee, Bo-ram& Kwon, Seung-Hae& Moon, Won-Jin& Hong, Kwan-Su…[et al.]. Novel Antidepressant-Like Activity of Caffeic Acid Phenethyl Ester Is Mediated by Enhanced Glucocorticoid Receptor Function in the Hippocampus. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035321
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035321
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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