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Effects of Ferulago angulata Extract on Serum Lipids and Lipid Peroxidation
المؤلفون المشاركون
Gharipour, Mojagn
Rafieian-kopaei, Mahmoud
Shahinfard, Najmeh
Darvishzadeh-Boroujeni, Pariya
Rouhi-Boroujeni, Hojjat
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-24
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Background.
Nowadays, herbs they are considered to be the main source of effective drugs for lowering serum lipids and lipid peroxidation.
The present experimental animal study aimed to assess the impact of Ferulago angulata on serum lipid profiles, and on levels of lipid peroxidation.
Methods.
Fifty male Wistar rats, weighing 250–300 g, were randomly divided into five equal groups (ten rats in each).
The rat groups received different diets as follows: Group I: fat-rich diet; Group II: fat-rich diet plus hydroalcoholic extracts of Ferulago angulata at a dose of 400 mg/kg; Group III: fat-rich diet plus hydroalcoholic extracts of Ferulago angulata at a dose of 600 mg/kg; Group IV: fat-rich diet plus atorvastatin; Group V: common stock diet.
The levels of serum glucose and lipids and the atherogenic index were measured.
In addition, malondialdehyde (MDA), thiol oxidation, carbonyl concentrations, C-reactive proteins, and antioxidant capacity were evaluated in each group of rats.
Results.
Interestingly, by adding a hydroalcoholic extract of Ferulago angulata to the high-fat diet, the levels of total cholesterol and low-density lipoproteins (LDL) in the high-fat diet rats were both significantly reduced.
This result was considerably greater compared to when atorvastatin was added as an antilipid drug.
The beneficial effects of the Ferulago angulata extract on lowering the level of triglycerides was observed only when a high dosage of this plant extraction was added to a high fat diet.
Furthermore, the level of malondialdehyde, was significantly affected by the use of the plant extract in a high-fat diet, compared with a normal regimen or high-fat diet alone.
Conclusion.
Administration of a hydroalcoholic extract of Ferulago angulata can reduce serum levels of total cholesterol, triglycerides, and LDL.
It can also inhibit lipid peroxidation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rafieian-kopaei, Mahmoud& Shahinfard, Najmeh& Rouhi-Boroujeni, Hojjat& Gharipour, Mojagn& Darvishzadeh-Boroujeni, Pariya. 2014. Effects of Ferulago angulata Extract on Serum Lipids and Lipid Peroxidation. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1035331
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rafieian-kopaei, Mahmoud…[et al.]. Effects of Ferulago angulata Extract on Serum Lipids and Lipid Peroxidation. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-1035331
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rafieian-kopaei, Mahmoud& Shahinfard, Najmeh& Rouhi-Boroujeni, Hojjat& Gharipour, Mojagn& Darvishzadeh-Boroujeni, Pariya. Effects of Ferulago angulata Extract on Serum Lipids and Lipid Peroxidation. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1035331
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035331
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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