Effect of Extracts of Terminalia chebula on Proliferation of Keratinocytes and Fibroblasts Cells: An Alternative Approach for Wound Healing
المؤلفون المشاركون
Singh, Dolly
Singh, Deepti
Choi, Soon Mo
Han, Sung Soo
Zo, Sun Mi
Painuli, Rakesh Mohan
Kwon, Sung Won
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-26
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Terminalia chebula is one of the traditional medicines used in the treatment of many diseases.
In the present work, different concentrations of various organic and aqueous extracts (solvent-free) of T.
chebula were tested on fibroblast (L929) and keratinocytes cells to evaluate its biocompatible concentration by using MTT and live-dead viability/cytotoxic assay.
These extracts were found to be effective in decreasing the ammonia accumulation in the media, thereby reducing its toxic effect on cells.
DPPH assay further confirmed the free-radical scavenging ability of the extracts which increased with the increase in concentration of each extract.
Cell proliferation/apoptosis, cytoskeletal structure, and ECM production were further evaluated by live-dead assay and phalloidin/cytokeratin staining, respectively.
The cytoskeletal structure and ECM secretion of the cells treated with extracts showed higher cellular activity in comparison to control.
In conclusion, we have demonstrated the effect of these extracts of T.
chebula on both types of skin cells and optimized concentration in which it could be used as a bioactive component for wound healing applications by increasing cell proliferation and decreasing free-radical production without affecting the normal cellular matrix.
It can also find applications in other therapeutics applications where ammonia toxicity is a limiting factor.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Singh, Dolly& Singh, Deepti& Choi, Soon Mo& Zo, Sun Mi& Painuli, Rakesh Mohan& Kwon, Sung Won…[et al.]. 2014. Effect of Extracts of Terminalia chebula on Proliferation of Keratinocytes and Fibroblasts Cells: An Alternative Approach for Wound Healing. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1035340
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Singh, Dolly…[et al.]. Effect of Extracts of Terminalia chebula on Proliferation of Keratinocytes and Fibroblasts Cells: An Alternative Approach for Wound Healing. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1035340
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Singh, Dolly& Singh, Deepti& Choi, Soon Mo& Zo, Sun Mi& Painuli, Rakesh Mohan& Kwon, Sung Won…[et al.]. Effect of Extracts of Terminalia chebula on Proliferation of Keratinocytes and Fibroblasts Cells: An Alternative Approach for Wound Healing. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1035340
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035340
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر