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Red Sea Suberea mollis Sponge Extract Protects against CCl4-Induced Acute Liver Injury in Rats via an Antioxidant Mechanism
المؤلفون المشاركون
Azhar, Esam
Abbas, Aymn T.
El-Shitany, Nagla A.
Shaala, Lamiaa A.
Ali, Soad S.
Abdel-dayem, Umama A.
Youssef, Diaa T. A.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Recent studies have demonstrated that marine sponges and their active constituents exhibited several potential medical applications.
This study aimed to evaluate the possible hepatoprotective role as well as the antioxidant effect of the Red Sea Suberea mollis sponge extract (SMSE) on carbon tetrachloride- (CCl4-) induced acute liver injury in rats.
In vitro antioxidant activity of SMSE was evaluated by 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) assay.
Rats were orally administered three different concentrations (100, 200, and 400 mg/kg) of SMSE and silymarin (100 mg/kg) along with CCl4 (1 mL/kg, i.p., every 72 hr) for 14 days.
Plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and total bilirubin were measured.
Hepatic malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NO), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were also measured.
Liver specimens were histopathologically examined.
SMSE showed strong scavenging activity against free radicals in DPPH assay.
SMSE significantly reduced liver enzyme activities.
Moreover, SMSE significantly reduced hepatic MDA formation.
In addition, SMSE restored GSH, NO, SOD, GPx, and CAT.
The histopathological results confirmed these findings.
The results of this study suggested a potent protective effect of the SMSE against CCl4-induced hepatic injury.
This may be due to its antioxidant and radical scavenging activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abbas, Aymn T.& El-Shitany, Nagla A.& Shaala, Lamiaa A.& Ali, Soad S.& Azhar, Esam& Abdel-dayem, Umama A.…[et al.]. 2014. Red Sea Suberea mollis Sponge Extract Protects against CCl4-Induced Acute Liver Injury in Rats via an Antioxidant Mechanism. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035356
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abbas, Aymn T.…[et al.]. Red Sea Suberea mollis Sponge Extract Protects against CCl4-Induced Acute Liver Injury in Rats via an Antioxidant Mechanism. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035356
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abbas, Aymn T.& El-Shitany, Nagla A.& Shaala, Lamiaa A.& Ali, Soad S.& Azhar, Esam& Abdel-dayem, Umama A.…[et al.]. Red Sea Suberea mollis Sponge Extract Protects against CCl4-Induced Acute Liver Injury in Rats via an Antioxidant Mechanism. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035356
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035356
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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