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Crotonis Fructus and Its Constituent, Croton Oil, Stimulate Lipolysis in OP9 Adipocytes
المؤلفون المشاركون
Kim, Ha-Rim
Kim, Mi-Seong
So, Hong-Seob
Moon, Hyoung-Chul
Ryu, Do-Gon
Yang, Sei-Hoon
Lee, Guem-San
Song, Je-Ho
Lee, Young-Rae
Kwon, Kang Beom
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-11
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Introduction.
Crotonis fructus (CF) is the mature fruit of Croton tiglium L.
and has been used for the treatment of gastrointestinal disturbance in Asia.
It is well known that the main component of CF is croton oil (CO).
The present study is to investigate the effects of CF extracts (CFE) and CO on lipolysis in OP9 adipocytes.
Methods.
Glycerol release to the culture supernatants was used as a marker of adipocyte lipolysis.
Results.
Treatment with various concentrations of CFE and CO stimulates glycerol release in a dose-dependent manner.
The increase in glycerol release by CFE is more potent than isoproterenol, which is a β-adrenergic agonist as a positive control in our system.
The increased lipolysis by CFE and CO was accompanied by an increase of phosphorylated hormone sensitive lipase (pHSL) but not nonphosphorylated HSL protein and mRNA.
Pretreatment with H89, which is a protein kinase A inhibitor, significantly abolished the CFE- and CO-induced glycerol release in OP9 adipocytes.
These results suggest that CFE and CO may be a candidate for the development of a lipolysis-stimulating agent in adipocytes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Mi-Seong& Kim, Ha-Rim& So, Hong-Seob& Lee, Young-Rae& Moon, Hyoung-Chul& Ryu, Do-Gon…[et al.]. 2014. Crotonis Fructus and Its Constituent, Croton Oil, Stimulate Lipolysis in OP9 Adipocytes. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1035365
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Mi-Seong…[et al.]. Crotonis Fructus and Its Constituent, Croton Oil, Stimulate Lipolysis in OP9 Adipocytes. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1035365
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Mi-Seong& Kim, Ha-Rim& So, Hong-Seob& Lee, Young-Rae& Moon, Hyoung-Chul& Ryu, Do-Gon…[et al.]. Crotonis Fructus and Its Constituent, Croton Oil, Stimulate Lipolysis in OP9 Adipocytes. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1035365
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035365
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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