Aqueous Extract of Phyllanthus niruri Leaves Displays In Vitro Antioxidant Activity and Prevents the Elevation of Oxidative Stress in the Kidney of Streptozotocin-Induced Diabetic Male Rats
المؤلفون المشاركون
Muniandy, Sekaran
Giribabu, Nelli
Swapna Rekha, Somesula
Kumar, Korla Praveen
Salleh, N.
Visweswara Rao, Pasupuleti
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-01
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
P.
niruri has been reported to possess antidiabetic and kidney protective effects.
In the present study, the phytochemical constituents and in vitro antioxidant activity of P.
niruri leaf aqueous extract were investigated together with its effect on oxidative stress and antioxidant enzymes levels in diabetic rat kidney.
Results.
Treatment of diabetic male rats with P.
niruri leaf aqueous extract (200 and 400 mg/kg) for 28 consecutive days prevents the increase in the amount of lipid peroxidation (LPO) product, malondialdehyde (MDA), and the diminution of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activity levels in the kidney of diabetic rats.
The amount of LPO showed strong negative correlation with SOD, CAT, and GPx activity levels.
P.
niruri leaf aqueous extract exhibits in vitro antioxidant activity with IC50 slightly lower than ascorbic acid.
Phytochemical screening of plant extract indicates the presence of polyphenols.
Conclusion.
P.
niruri leaf extract protects the kidney from oxidative stress induced by diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Giribabu, Nelli& Visweswara Rao, Pasupuleti& Kumar, Korla Praveen& Muniandy, Sekaran& Swapna Rekha, Somesula& Salleh, N.. 2014. Aqueous Extract of Phyllanthus niruri Leaves Displays In Vitro Antioxidant Activity and Prevents the Elevation of Oxidative Stress in the Kidney of Streptozotocin-Induced Diabetic Male Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035394
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Giribabu, Nelli…[et al.]. Aqueous Extract of Phyllanthus niruri Leaves Displays In Vitro Antioxidant Activity and Prevents the Elevation of Oxidative Stress in the Kidney of Streptozotocin-Induced Diabetic Male Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035394
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Giribabu, Nelli& Visweswara Rao, Pasupuleti& Kumar, Korla Praveen& Muniandy, Sekaran& Swapna Rekha, Somesula& Salleh, N.. Aqueous Extract of Phyllanthus niruri Leaves Displays In Vitro Antioxidant Activity and Prevents the Elevation of Oxidative Stress in the Kidney of Streptozotocin-Induced Diabetic Male Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035394
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035394
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر