Pharmacokinetics of Two Alkaloids after Oral Administration of Rhizoma Coptidis Extract in Normal Rats and Irritable Bowel Syndrome Rats

المؤلفون المشاركون

Gong, Zipeng
Chen, Ying
Zhang, Ruijie
Wang, Yinghan
Yang, Qing
Guo, Yan
Weng, Xiaogang
Gao, Shuangrong
Wang, Hailin
Zhu, Xiaoxin
Dong, Yu
Wang, Yajie
Li, Yujie

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-08-27

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص EN

A comparative pharmacokinetic study of berberine and palmatine after oral administration of Rhizoma Coptidis extract (96 mg/kg, containing berberine 22 mg/kg and palmatine 5 mg/kg based on body weight) was performed in normal and postinflammation irritable bowel syndrome (PI-IBS) rats, induced by intracolonic instillation of acetic acid and restraint stress.

Quantification of berberine and palmatine in rat plasma was achieved by using a sensitive and rapid UPLC-MS/MS method.

Plasma samples were collected at 13 different time points and the pharmacokinetic parameters were analyzed by WinNonlin software.

The significant differences in the pharmacokinetic behaviors, such as C max , AUC ( 0 – t ) , V d / F , and CL/ F , of berberine and palmatine were found between normal and PI-IBS model rats.

The results indicated that PI-IBS pathological conditions in rats could alter the pharmacokinetic behavior of drug.

Preclinical pharmacokinetic studies are usually carried out on healthy animals.

However, we should pay more attention to the fact that the change of pharmacokinetic behavior plays an important role on efficacy.

It is essential to investigate the pharmacokinetics of the drug in disease status.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Gong, Zipeng& Chen, Ying& Zhang, Ruijie& Wang, Yinghan& Yang, Qing& Guo, Yan…[et al.]. 2014. Pharmacokinetics of Two Alkaloids after Oral Administration of Rhizoma Coptidis Extract in Normal Rats and Irritable Bowel Syndrome Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035415

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Gong, Zipeng…[et al.]. Pharmacokinetics of Two Alkaloids after Oral Administration of Rhizoma Coptidis Extract in Normal Rats and Irritable Bowel Syndrome Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035415

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Gong, Zipeng& Chen, Ying& Zhang, Ruijie& Wang, Yinghan& Yang, Qing& Guo, Yan…[et al.]. Pharmacokinetics of Two Alkaloids after Oral Administration of Rhizoma Coptidis Extract in Normal Rats and Irritable Bowel Syndrome Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035415

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1035415