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In Silico Design for Adenosine Monophosphate-Activated Protein Kinase Agonist from Traditional Chinese Medicine for Treatment of Metabolic Syndromes
المؤلفون المشاركون
Chen, Calvin Yu-Chian
Tang, Hsin-Chieh
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-08
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Adenosine monophosphate-activated protein kinase (AMPK) acts as a master mediator of metabolic homeostasis.
It is considered as a significant millstone to treat metabolic syndromes including obesity, diabetes, and fatty liver.
It can sense cellular energy or nutrient status by switching on the catabolic pathways.
Investigation of AMPK has new findings recently.
AMPK can inhibit cell growth by the way of autophagy.
Thus AMPK has become a hot target for small molecular drug design of tumor inhibition.
Activation of AMPK must undergo certain extent change of the structure.
Through the methods of structure-based virtual screening and molecular dynamics simulation, we attempted to find out appropriate small compounds from the world’s largest TCM Database@Taiwan that had the ability to activate the function of AMPK.
Finally, we found that two TCM compounds, eugenyl_beta-D-glucopyranoside and 6-O-cinnamoyl-D-glucopyranose, had the qualification to be AMPK agonist.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tang, Hsin-Chieh& Chen, Calvin Yu-Chian. 2014. In Silico Design for Adenosine Monophosphate-Activated Protein Kinase Agonist from Traditional Chinese Medicine for Treatment of Metabolic Syndromes. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1035462
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tang, Hsin-Chieh& Chen, Calvin Yu-Chian. In Silico Design for Adenosine Monophosphate-Activated Protein Kinase Agonist from Traditional Chinese Medicine for Treatment of Metabolic Syndromes. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1035462
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tang, Hsin-Chieh& Chen, Calvin Yu-Chian. In Silico Design for Adenosine Monophosphate-Activated Protein Kinase Agonist from Traditional Chinese Medicine for Treatment of Metabolic Syndromes. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1035462
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035462
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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