Updates on the Clinical Evidenced Herb-Warfarin Interactions
المؤلفون المشاركون
Ge, Beikang
Zhang, Zhen
Zuo, Zhong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-18
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Increasing and inadvertent use of herbs makes herb-drug interactions a focus of research.
Concomitant use of warfarin, a highly efficacious oral anticoagulant, and herbs causes major safety concerns due to the narrow therapeutic window of warfarin.
This paper presents an update overview of clinical findings regarding herb-warfarin interaction, highlighting clinical outcomes, severity of documented interactions, and quality of clinical evidence.
Among thirty-eight herbs, Cannabis, Chamomile, Cranberry, Garlic, Ginkgo, Grapefruit, Lycium, Red clover, and St.
John’s wort were evaluated to have major severity interaction with warfarin.
Herbs were also classified on account of the likelihood of their supporting evidences for interaction.
Four herbs were considered as highly probable to interact with warfarin (level I), three were estimated as probable (level II), and ten and twenty-one were possible (level III) and doubtful (level IV), respectively.
The general mechanism of herb-warfarin interaction almost remains unknown, yet several pharmacokinetic and pharmacodynamic factors were estimated to influence the effectiveness of warfarin.
Based on limited literature and information reported, we identified corresponding mechanisms of interactions for a small amount of “interacting herbs.” In summary, herb-warfarin interaction, especially the clinical effects of herbs on warfarin therapy should be further investigated through multicenter studies with larger sample sizes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ge, Beikang& Zhang, Zhen& Zuo, Zhong. 2014. Updates on the Clinical Evidenced Herb-Warfarin Interactions. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-1035484
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ge, Beikang…[et al.]. Updates on the Clinical Evidenced Herb-Warfarin Interactions. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-18.
https://search.emarefa.net/detail/BIM-1035484
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ge, Beikang& Zhang, Zhen& Zuo, Zhong. Updates on the Clinical Evidenced Herb-Warfarin Interactions. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-1035484
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035484
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر