Effect of Cervus and Cucumis Peptides on Osteoblast Activity and Fracture Healing in Osteoporotic Bone
المؤلفون المشاركون
Peng, Jiang
Wang, Ai-Yuan
Tian, Yue
Yuan, Mei
Zhang, Li
Chen, Ji-Feng
Xu, Wen-Jing
Meng, Hao-Ye
Yu, Xiao-Ming
Wang, Yao-Qin
Guo, Quan-Yi
Lu, Shi-Bi
Wang, Yu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-07
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Osteoporosis is associated with delayed and/or reduced fracture healing.
As cervus and cucumis are the traditional Chinese treatments for rheumatoid arthritis, we investigated the effect of supplementation of these peptides (CCP) on bone fracture healing in ovariectomized (OVX) osteoporotic rats in vitro and in vivo.
CCP enhanced osteoblast proliferation and increased alkaline phosphatase activity, matrix mineralization, and expression of runt-related transcription factor 2 (Runx2), bone morphogenetic protein 4 (BMP4), and osteopontin.
In vivo, female Sprague-Dawley rats underwent ovariectomy and the right femora were fractured and fixed by intramedullary nailing 3 months later.
Rats received intraperitoneal injections of either CCP (1.67 mg/kg) or physiological saline every day for 30 days.
Fracture healing and callus formation were evaluated by radiography, micro-CT, biomechanical testing, and histology.
At 12 weeks after fracture, calluses in CCP-treated bones showed significantly higher torsional strength and greater stiffness than control-treated bones.
Bones in CCP-treated rats reunified and were thoroughly remodeled, while two saline-treated rats showed no bone union and incomplete remodeling.
Taken together, these results indicate that use of CCP after fracture in osteoporotic rats accelerates mineralization and osteogenesis and improves fracture healing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Ai-Yuan& Tian, Yue& Yuan, Mei& Zhang, Li& Chen, Ji-Feng& Xu, Wen-Jing…[et al.]. 2014. Effect of Cervus and Cucumis Peptides on Osteoblast Activity and Fracture Healing in Osteoporotic Bone. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035489
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Ai-Yuan…[et al.]. Effect of Cervus and Cucumis Peptides on Osteoblast Activity and Fracture Healing in Osteoporotic Bone. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035489
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Ai-Yuan& Tian, Yue& Yuan, Mei& Zhang, Li& Chen, Ji-Feng& Xu, Wen-Jing…[et al.]. Effect of Cervus and Cucumis Peptides on Osteoblast Activity and Fracture Healing in Osteoporotic Bone. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035489
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035489
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر