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Naja naja atra Venom Protects against Manifestations of Systemic Lupus Erythematosus in MRLlpr Mice
المؤلفون المشاركون
Kou, Jian-Qun
Han, Rong
Xu, Yin-Li
Ding, Zhi-Hui
Cui, Kui
Qin, Zheng-Hong
Zhu, Jia-Li
Wang, Shu-Zhi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-30
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Systemic lupus erythematosus (SLE) is an autoimmune disease and effective therapy for this pathology is currently unavailable.
We previously reported that oral administration of Naja naja atra venom (NNAV) had anti-inflammatory and immune regulatory actions.
We speculated that NNAV may have therapeutic effects in MRL/lpr SLE mice.
Twelve-week-old MRL/lpr mice received oral administration of NNAV (20, 40, and 80 μg/kg) or Tripterygium wilfordii polyglycosidium (10 mg/kg) daily for 16 weeks.
The effects of NNAV on SLE manifestations, including skin erythema, proteinuria, and anxiety-like behaviors, were assessed with visual inspection and Multistix 8 SG strips and open field test, respectively.
The pathology of spleen and kidney was examined with H&E staining.
The changes in autoimmune antibodies and cytokines were determined with ELISA kits.
The results showed that NNAV protected against the manifestation of SLE, including skin erythema and proteinuria.
In addition, although no apparent histological change was found in liver and heart in MRL/lpr SLE mice, NNAV reduced the levels of glutamate pyruvate transaminase and creatine kinase.
Furthermore, NNAV increased serum C3 and reduced concentrations of circulating globulin, anti-dsDNA antibody, and inflammatory cytokines IL-6 and TNF- α .
NNAV also reduced lymphadenopathy and renal injury.
These results suggest that NNAV may have therapeutic values in the treatment of SLE by inhibiting autoimmune responses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhu, Jia-Li& Cui, Kui& Kou, Jian-Qun& Wang, Shu-Zhi& Xu, Yin-Li& Ding, Zhi-Hui…[et al.]. 2014. Naja naja atra Venom Protects against Manifestations of Systemic Lupus Erythematosus in MRLlpr Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035506
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhu, Jia-Li…[et al.]. Naja naja atra Venom Protects against Manifestations of Systemic Lupus Erythematosus in MRLlpr Mice. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1035506
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhu, Jia-Li& Cui, Kui& Kou, Jian-Qun& Wang, Shu-Zhi& Xu, Yin-Li& Ding, Zhi-Hui…[et al.]. Naja naja atra Venom Protects against Manifestations of Systemic Lupus Erythematosus in MRLlpr Mice. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035506
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035506
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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