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Antidiabetic and Antihyperlipidemic Effects of Clitocybe nuda on Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation in High-Fat-Fed Mice
المؤلفون المشاركون
Chen, Mei-Hsing
Shih, Chun-Ching
Lin, Cheng-Hsiu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-16
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The objective of this study was to evaluate the antihyperlipidemic and antihyperglycemic effects and mechanism of the extract of Clitocybe nuda (CNE), in high-fat- (HF-) fed mice.
C57BL/6J was randomly divided into two groups: the control (CON) group was fed with a low-fat diet, whereas the experimental group was fed with a HF diet for 8 weeks.
Then, the HF group was subdivided into five groups and was given orally CNE (including C1: 0.2, C2: 0.5, and C3: 1.0 g/kg/day extracts) or rosiglitazone (Rosi) or vehicle for 4 weeks.
CNE effectively prevented HF-diet-induced increases in the levels of blood glucose, triglyceride, insulin ( P < 0.001 , P < 0.01 , P < 0.05 , resp.) and attenuated insulin resistance.
By treatment with CNE, body weight gain, weights of white adipose tissue (WAT) and hepatic triacylglycerol content were reduced; moreover, adipocytes in the visceral depots showed a reduction in size.
By treatment with CNE, the protein contents of glucose transporter 4 (GLUT4) were significantly increased in C3-treated group in the skeletal muscle.
Furthermore, CNE reduces the hepatic expression of glucose-6-phosphatase (G6Pase) and glucose production.
CNE significantly increases protein contents of phospho-AMP-activated protein kinase (AMPK) in the skeletal muscle and adipose and liver tissues.
Therefore, it is possible that the activation of AMPK by CNE leads to diminished gluconeogenesis in the liver and enhanced glucose uptake in skeletal muscle.
It is shown that CNE exhibits hypolipidemic effect in HF-fed mice by increasing ATGL expression, which is known to help triglyceride to hydrolyze.
Moreover, antidiabetic properties of CNE occurred as a result of decreased hepatic glucose production via G6Pase downregulation and improved insulin sensitization.
Thus, amelioration of diabetic and dyslipidemic states by CNE in HF-fed mice occurred by regulation of GLUT4, G6Pase, ATGL, and AMPK phosphorylation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Mei-Hsing& Lin, Cheng-Hsiu& Shih, Chun-Ching. 2014. Antidiabetic and Antihyperlipidemic Effects of Clitocybe nuda on Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation in High-Fat-Fed Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1035522
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Mei-Hsing…[et al.]. Antidiabetic and Antihyperlipidemic Effects of Clitocybe nuda on Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation in High-Fat-Fed Mice. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1035522
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Mei-Hsing& Lin, Cheng-Hsiu& Shih, Chun-Ching. Antidiabetic and Antihyperlipidemic Effects of Clitocybe nuda on Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation in High-Fat-Fed Mice. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1035522
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035522
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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