![](/images/graphics-bg.png)
The Role of e-NOS in Chronic Cholestasis-Induced Liver and Renal Injury in Rats: The Effect of N-Acetyl Cysteine
المؤلفون المشاركون
Altaner, Semsi
Ekmen, Nergiz
Gunay, Yusuf
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction.
The role of chronic cholestasis (CC) in liver injury and fibrosis remains unclear.
The aims of this study were to define the role of endothelial nitric oxide synthase (e-NOS) in CC and the protective effect of N-acetyl-L-cysteine (NAC) in liver and kidney injury.
Materials and Methods.
Group A (sham group); Group B (CBDL); and Group C (CBDL + NAC).
Group C received daily dosage of NAC (100 mg/kg) intraperitoneally for up to 4 weeks.
Results.
The rate of bridging fibrosis was higher (100% versus 20%, P=.025), but the intensity of e-NOS in liver was lower in rats that received NAC (1.3 versus 2.7, P=.046).
The necrotic area in the kidneys among rats that received NAC was lower at week 4 (48% versus 57%; P<.001).
The numbers of e-NOS stained cells in kidney were similar in sham group and the two groups with CBDL.
Discussion.
NAC reduced the stimulus for liver fibrosis in this rat model of CC and attenuated liver and kidney injury.
Our study showed that e-NOS expression increased in liver tissue of rats with CC and that this was reversed by NAC.
Treatment with NAC might restore e-NOS protein expression and prevent liver injury in CC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gunay, Yusuf& Altaner, Semsi& Ekmen, Nergiz. 2014. The Role of e-NOS in Chronic Cholestasis-Induced Liver and Renal Injury in Rats: The Effect of N-Acetyl Cysteine. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035893
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gunay, Yusuf…[et al.]. The Role of e-NOS in Chronic Cholestasis-Induced Liver and Renal Injury in Rats: The Effect of N-Acetyl Cysteine. Gastroenterology Research and Practice No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035893
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gunay, Yusuf& Altaner, Semsi& Ekmen, Nergiz. The Role of e-NOS in Chronic Cholestasis-Induced Liver and Renal Injury in Rats: The Effect of N-Acetyl Cysteine. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035893
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035893
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)