Altered Proteolysis in Fibroblasts of Alzheimer Patients with Predictive Implications for Subjects at Risk of Disease
المؤلفون المشاركون
Sanchez, Luis
Pani, Alessandra
Mocali, Alessandra
Boddi, Vieri
Della Malva, Nunzia
Abete, Claudia
Mitidieri Costanza, Vito Antonio
Bavazzano, Antonio
Dessì, Sandra
Paoletti, Francesco
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
There is great interest in developing reliable biomarkers to support antemortem diagnosis of late-onset Alzheimer’s disease (AD).
Early prediction and diagnosis of AD might be improved by the detection of a proteolytic dysfunction in extracts from cultured AD fibroblasts, producing altered isoelectrophoretic forms of the enzyme transketolase (TK-alkaline bands).
The TK profile and apolipoprotein E (APOE) genotype were examined in fibroblasts from 36 clinically diagnosed probable late-onset sporadic AD patients and 38 of their asymptomatic relatives, 29 elderly healthy individuals, 12 neurological non-AD patients, and 5 early-onset AD patients.
TK alterations occurred in (i) several probable AD patients regardless of age-of-onset and severity of disease; (ii) all early-onset AD patients and APOE ε4/4 carriers; and (iii) nearly half of asymptomatic AD relatives.
Normal subjects and non-AD patients were all negative.
Notably, culture conditions promoting TK alterations were also effective in increasing active BACE1 levels.
Overall, the TK assay might represent a low-cost laboratory tool useful for supporting AD differential diagnosis and identifying asymptomatic subjects who are at greater risk of AD and who should enter a follow-up study.
Moreover, the cultured fibroblasts were confirmed as a useful in vitro model for further studies on the pathogenetic process of AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mocali, Alessandra& Della Malva, Nunzia& Abete, Claudia& Mitidieri Costanza, Vito Antonio& Bavazzano, Antonio& Boddi, Vieri…[et al.]. 2014. Altered Proteolysis in Fibroblasts of Alzheimer Patients with Predictive Implications for Subjects at Risk of Disease. International Journal of Alzheimer's Disease،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035948
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mocali, Alessandra…[et al.]. Altered Proteolysis in Fibroblasts of Alzheimer Patients with Predictive Implications for Subjects at Risk of Disease. International Journal of Alzheimer's Disease No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035948
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mocali, Alessandra& Della Malva, Nunzia& Abete, Claudia& Mitidieri Costanza, Vito Antonio& Bavazzano, Antonio& Boddi, Vieri…[et al.]. Altered Proteolysis in Fibroblasts of Alzheimer Patients with Predictive Implications for Subjects at Risk of Disease. International Journal of Alzheimer's Disease. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035948
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035948
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر