Differential Network Analyses of Alzheimer’s Disease Identify Early Events in Alzheimer’s Disease Pathology
المؤلفون المشاركون
Xia, Jing
Perry, George
Rocke, David M.
Ray, Monika
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-23
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
In late-onset Alzheimer’s disease (AD), multiple brain regions are not affected simultaneously.
Comparing the gene expression of the affected regions to identify the differences in the biological processes perturbed can lead to greater insight into AD pathogenesis and early characteristics.
We identified differentially expressed (DE) genes from single cell microarray data of four AD affected brain regions: entorhinal cortex (EC), hippocampus (HIP), posterior cingulate cortex (PCC), and middle temporal gyrus (MTG).
We organized the DE genes in the four brain regions into region-specific gene coexpression networks.
Differential neighborhood analyses in the coexpression networks were performed to identify genes with low topological overlap (TO) of their direct neighbors.
The low TO genes were used to characterize the biological differences between two regions.
Our analyses show that increased oxidative stress, along with alterations in lipid metabolism in neurons, may be some of the very early events occurring in AD pathology.
Cellular defense mechanisms try to intervene but fail, finally resulting in AD pathology as the disease progresses.
Furthermore, disease annotation of the low TO genes in two independent protein interaction networks has resulted in association between cancer, diabetes, renal diseases, and cardiovascular diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xia, Jing& Rocke, David M.& Perry, George& Ray, Monika. 2014. Differential Network Analyses of Alzheimer’s Disease Identify Early Events in Alzheimer’s Disease Pathology. International Journal of Alzheimer's Disease،Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-1035950
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xia, Jing…[et al.]. Differential Network Analyses of Alzheimer’s Disease Identify Early Events in Alzheimer’s Disease Pathology. International Journal of Alzheimer's Disease No. 2014 (2014), pp.1-18.
https://search.emarefa.net/detail/BIM-1035950
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xia, Jing& Rocke, David M.& Perry, George& Ray, Monika. Differential Network Analyses of Alzheimer’s Disease Identify Early Events in Alzheimer’s Disease Pathology. International Journal of Alzheimer's Disease. 2014. Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-1035950
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035950
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر