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Modulation of the Activities of Catalase, Cu-Zn, Mn Superoxide Dismutase, and Glutathione Peroxidase in Adipocyte from Ovariectomised Female Rats with Metabolic Syndrome
المؤلفون المشاركون
Guerra, Rebeca Cambray
Zuñiga-Muñoz, Alejandra
Guarner Lans, Verónica
Díaz-Díaz, Eulises
Tena Betancourt, Carlos Alberto
Pérez-Torres, Israel
المصدر
International Journal of Endocrinology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-29
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The aim of this study was to evaluate the association between estrogen removal, antioxidant enzymes, and oxidative stress generated by obesity in a MS female rat model.
Thirty two female Wistar rats were divided into 4 groups: Control (C), MS, MS ovariectomized (Ovx), and MS Ovx plus estradiol (E2).
MS was induced by administering 30% sucrose to drinking water for 24 weeks.
After sacrifice, intra-abdominal fat was dissected; adipocytes were isolated and lipid peroxidation, non-enzymatic antioxidant capacity, and the activities of Cu-Zn and Mn superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were determined.
There were no significant differences in the activities of Cu-Zn, Mn SOD, CAT, and GPx between the C and MS groups, but in the MS Ovx group there was a statistically significant decrease in the activities of these enzymes when compared to MS and MS Ovx+E2.
The increased lipid peroxidation and nonenzymatic antioxidant capacity found in MS Ovx was significantly decreased when compared to MS and MS Ovx+E2.
In conclusion, the removal of E2 by ovariectomy decreases the activity of the antioxidant enzymes in the intra-abdominal tissue of MS female rats; this is reflected by increased lipid peroxidation and decreased nonenzymatic antioxidant capacity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guerra, Rebeca Cambray& Zuñiga-Muñoz, Alejandra& Guarner Lans, Verónica& Díaz-Díaz, Eulises& Tena Betancourt, Carlos Alberto& Pérez-Torres, Israel. 2014. Modulation of the Activities of Catalase, Cu-Zn, Mn Superoxide Dismutase, and Glutathione Peroxidase in Adipocyte from Ovariectomised Female Rats with Metabolic Syndrome. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1036424
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guerra, Rebeca Cambray…[et al.]. Modulation of the Activities of Catalase, Cu-Zn, Mn Superoxide Dismutase, and Glutathione Peroxidase in Adipocyte from Ovariectomised Female Rats with Metabolic Syndrome. International Journal of Endocrinology No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1036424
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guerra, Rebeca Cambray& Zuñiga-Muñoz, Alejandra& Guarner Lans, Verónica& Díaz-Díaz, Eulises& Tena Betancourt, Carlos Alberto& Pérez-Torres, Israel. Modulation of the Activities of Catalase, Cu-Zn, Mn Superoxide Dismutase, and Glutathione Peroxidase in Adipocyte from Ovariectomised Female Rats with Metabolic Syndrome. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1036424
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036424
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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