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The Association between IGF-1 Polymorphisms, IGF-1 Serum Levels, and Cognitive Functions in Healthy Adults: The Amsterdam Growth and Health Longitudinal Study
المؤلفون المشاركون
Deijen, Jan Berend
Licht, Carmilla M. M.
van Turenhout, Lise C.
Koppes, Lando L. J.
Twisk, Jos W. R.
van Mechelen, Willem
Drent, Madeleine L.
المصدر
International Journal of Endocrinology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-10
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Several studies have demonstrated an association between polymorphisms in the insulin-like growth factor-1 (IGF-1) gene and IGF-1 serum levels.
IGF-1 levels have been associated with cognitive functioning in older persons and growth hormone deficient patients.
The present study investigates whether IGF-1 polymorphisms, IGF-1 levels, and cognition are interconnected in healthy adults.
Data of 277 participants (mean age: 42.4 years) of the Amsterdam Growth and Health Longitudinal Study on IGF-1 promoter polymorphisms, IGF-1 serum level, spatial working memory (SWM), paired associate learning (PAL), and IQ tests were analyzed.
(M)ANOVAs were applied to confirm the associations between IGF-1 polymorphisms and IGF-1 levels and between IGF-1 levels and cognition.
Three groups were distinguished based on specific IGF-1 polymorphism alleles: a homozygote 192 bp/192 bp genotype, a heterozygote 192 bp/x genotype, and a noncarrier x/x genotype.
Although different IGF-1 levels were found for the three genotypes, performance on all cognitive tasks and IQ measures was similar.
Despite the associations between IGF-1 polymorphisms and IGF-1 levels, no association was found between cognition and IGF-1 levels.
It seems that IGF-1 does not play a role in the cognitive performance of healthy middle-aged adults.
Possible, IGF-1 fulfills a more developmental and protective role in cognition which becomes apparent during childhood, old-age, or disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Licht, Carmilla M. M.& van Turenhout, Lise C.& Deijen, Jan Berend& Koppes, Lando L. J.& van Mechelen, Willem& Twisk, Jos W. R.…[et al.]. 2014. The Association between IGF-1 Polymorphisms, IGF-1 Serum Levels, and Cognitive Functions in Healthy Adults: The Amsterdam Growth and Health Longitudinal Study. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036426
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Licht, Carmilla M. M.…[et al.]. The Association between IGF-1 Polymorphisms, IGF-1 Serum Levels, and Cognitive Functions in Healthy Adults: The Amsterdam Growth and Health Longitudinal Study. International Journal of Endocrinology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1036426
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Licht, Carmilla M. M.& van Turenhout, Lise C.& Deijen, Jan Berend& Koppes, Lando L. J.& van Mechelen, Willem& Twisk, Jos W. R.…[et al.]. The Association between IGF-1 Polymorphisms, IGF-1 Serum Levels, and Cognitive Functions in Healthy Adults: The Amsterdam Growth and Health Longitudinal Study. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036426
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036426
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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