Ovarian and Adrenal Androgens and Their Link to High Human Chorionic Gonadotropin Levels: A Prospective Controlled Study
المؤلفون المشاركون
Villarreal-Pérez, Jesús Zacarías
Morales-Martinez, Felipe Arturo
Rodríguez-Guajardo, René
González-Saldivar, Gloria
Mancillas-Adame, Leonardo G.
Alvarez-Villalobos, Neri Alejandro
Lavalle-Gonzalez, Fernando Javier
González-González, José Gerardo
Rodríguez-Gutiérrez, René
المصدر
International Journal of Endocrinology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Although the association between human chorionic gonadotropin (hCG) and hyperandrogenism was identified more than 40 years ago, relevant questions remain unanswered.
Design and Methods.
We conducted a prospective, longitudinal, and controlled study in 23 women with a diagnosis of a complete hydatidiform mole (HM).
Results.
All participants completed the study.
Before HM evacuation mean hCG was markedly higher in the cases than in the control group ( P ≤ 0.001 ).
Free testosterone (T) and dehydroepiandrosterone sulfate (DHEA-S) were found to be higher in the cases (2.78 ± 1.24 pg/mL and 231.50 ± 127.20 μ/dL) when compared to the control group (1.50 ± 0.75 pg/mL and 133.59 ± 60.69 μ/dL) ( P = 0.0001 and 0.001), respectively.
There was a strong correlation between hCG and free T/total T/DHEA-S concentrations ( r = 0.78 ; P ≤ 0.001 , r = 0.74 ; P ≤ 0.001 , and r = 0.71 ; P ≤ 0.001 ), respectively.
In the cases group 48 hours after HM evacuation, hCG levels were found to be significantly lower when compared to initial levels ( P = 0.001 ) and free T and DHEA-S declined significantly ( P = 0.0002 and 0.009).
Conclusion.
Before uterus evacuation, hCG, free T, and DHEA-S levels were significantly higher when compared with controls finding a strong correlation between hCG and free T/DHEA-S levels.
Forty-eight hours after HM treatment hCG levels declined and the difference was lost.
A novel finding of our study is that in cases, besides free T, DHEA-S was also found to be significantly higher and both the ovaries and adrenal glands appear to be the sites of this androgen overproduction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rodríguez-Gutiérrez, René& Villarreal-Pérez, Jesús Zacarías& Morales-Martinez, Felipe Arturo& Rodríguez-Guajardo, René& González-Saldivar, Gloria& Mancillas-Adame, Leonardo G.…[et al.]. 2014. Ovarian and Adrenal Androgens and Their Link to High Human Chorionic Gonadotropin Levels: A Prospective Controlled Study. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036429
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rodríguez-Gutiérrez, René…[et al.]. Ovarian and Adrenal Androgens and Their Link to High Human Chorionic Gonadotropin Levels: A Prospective Controlled Study. International Journal of Endocrinology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1036429
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rodríguez-Gutiérrez, René& Villarreal-Pérez, Jesús Zacarías& Morales-Martinez, Felipe Arturo& Rodríguez-Guajardo, René& González-Saldivar, Gloria& Mancillas-Adame, Leonardo G.…[et al.]. Ovarian and Adrenal Androgens and Their Link to High Human Chorionic Gonadotropin Levels: A Prospective Controlled Study. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036429
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036429
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر