Adrenal Disorders and the Paediatric Brain: Pathophysiological Considerations and Clinical Implications
المؤلفون المشاركون
Salpietro, Vincenzo
Polizzi, Agata
Di Rosa, Gabriella
Romeo, Anna Claudia
Dipasquale, Valeria
Morabito, Paolo
Chirico, Valeria
Arrigo, Teresa
Ruggieri, Martino
المصدر
International Journal of Endocrinology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-03
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Various neurological and psychiatric manifestations have been recorded in children with adrenal disorders.
Based on literature review and on personal case-studies and case-series we focused on the pathophysiological and clinical implications of glucocorticoid-related, mineralcorticoid-related, and catecholamine-related paediatric nervous system involvement.
Childhood Cushing syndrome can be associated with long-lasting cognitive deficits and abnormal behaviour, even after resolution of the hypercortisolism.
Exposure to excessive replacement of exogenous glucocorticoids in the paediatric age group (e.g., during treatments for adrenal insufficiency) has been reported with neurological and magnetic resonance imaging (MRI) abnormalities (e.g., delayed myelination and brain atrophy) due to potential corticosteroid-related myelin damage in the developing brain and the possible impairment of limbic system ontogenesis.
Idiopathic intracranial hypertension (IIH), a disorder of unclear pathophysiology characterised by increased cerebrospinal fluid (CSF) pressure, has been described in children with hypercortisolism, adrenal insufficiency, and hyperaldosteronism, reflecting the potential underlying involvement of the adrenal-brain axis in the regulation of CSF pressure homeostasis.
Arterial hypertension caused by paediatric adenomas or tumours of the adrenal cortex or medulla has been associated with various hypertension-related neurological manifestations.
The development and maturation of the central nervous system (CNS) through childhood is tightly regulated by intrinsic, paracrine, endocrine, and external modulators, and perturbations in any of these factors, including those related to adrenal hormone imbalance, could result in consequences that affect the structure and function of the paediatric brain.
Animal experiments and clinical studies demonstrated that the developing (i.e., paediatric) CNS seems to be particularly vulnerable to alterations induced by adrenal disorders and/or supraphysiological doses of corticosteroids.
Physicians should be aware of potential neurological manifestations in children with adrenal dysfunction to achieve better prevention and timely diagnosis and treatment of these disorders.
Further studies are needed to explore the potential neurological, cognitive, and psychiatric long-term consequences of high doses of prolonged corticosteroid administration in childhood.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Salpietro, Vincenzo& Polizzi, Agata& Di Rosa, Gabriella& Romeo, Anna Claudia& Dipasquale, Valeria& Morabito, Paolo…[et al.]. 2014. Adrenal Disorders and the Paediatric Brain: Pathophysiological Considerations and Clinical Implications. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1036448
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Salpietro, Vincenzo…[et al.]. Adrenal Disorders and the Paediatric Brain: Pathophysiological Considerations and Clinical Implications. International Journal of Endocrinology No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1036448
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Salpietro, Vincenzo& Polizzi, Agata& Di Rosa, Gabriella& Romeo, Anna Claudia& Dipasquale, Valeria& Morabito, Paolo…[et al.]. Adrenal Disorders and the Paediatric Brain: Pathophysiological Considerations and Clinical Implications. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1036448
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036448
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر