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Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes
المؤلفون المشاركون
Martinell, Mats
Carlsson, Per-Ola
Espes, Daniel
المصدر
International Journal of Endocrinology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-22
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Betatrophin has recently been described as a key hormone to stimulate beta-cell mass expansion in response to insulin resistance and obesity in mice.
The finding has generated an interest in the development of antidiabetic drugs with betatrophin as the active component.
However, the circulating levels of betatrophin in patients with type 2 diabetes are not well known.
Betatrophin concentrations in plasma of 27 type 2 diabetes patients and 18 gender-, age-, and BMI-matched controls were measured.
Study participants were characterized with regard to BMI, waist and hip circumference, blood pressure, and fasting plasma blood lipids, creatinine, glucose, HbA1c, and C-peptide.
HOMA2 indices were calculated.
Betatrophin was 40% higher in patients with type 2 diabetes (893±80 versus 639±66 pg/mL).
Betatrophin positively correlated with age in the controls and with HbA1c in the type 2 diabetes patients.
All study participants were insulin resistant with mean HOMA2B IR in both groups exceeding 2 and HOMA2%S<50%.
Control individuals had impaired fasting glucose concentrations.
In this report on betatrophin concentrations in type 2 diabetes and insulin resistance, elevated betatrophin levels were measured in the patients with type 2 diabetes.
Future studies are clearly needed to delineate the exact role, if any, of betatrophin in regulating human beta-cell mass.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Espes, Daniel& Martinell, Mats& Carlsson, Per-Ola. 2014. Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036467
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Espes, Daniel…[et al.]. Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes. International Journal of Endocrinology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1036467
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Espes, Daniel& Martinell, Mats& Carlsson, Per-Ola. Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036467
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036467
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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