Long-Term Follow-Up of Patients with 46,XY Partial Gonadal Dysgenesis Reared as Males
المؤلفون المشاركون
Gabriel Ribeiro de Andrade, Juliana
Marques-de-Faria, Antonia Paula
Fabbri, Helena Campos
Maciel-Guerra, Andréa Trevas
Guerra-Junior, Gil
de Mello, Maricilda Palandi
المصدر
International Journal of Endocrinology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-14
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background/Aims.
Studies on 46,XY partial gonadal dysgenesis (PGD) have focused on molecular, gonadal, genital, and hormone features; little is known about follow-up.
Our aim was to analyze long-term outcomes of PGD.
Methods.
Retrospective longitudinal study conducted at a reference service in Brazil.
Ten patients were first evaluated in the 1990s and followed up until the 2010s; follow-up ranged from 13.5 to 19.7 years.
All were reared as males and had at least one scrotal testis; two bore NR5A1 mutations.
Main outcomes were: associated conditions, pubertal development, and growth.
Results.
All patients had normal motor development but three presented cognitive impairment; five had various associated conditions.
At the end of the prepubertal period, FSH was high or high-normal in 3/6 patients; LH was normal in all.
At the last evaluation, FSH was high or high-normal in 8/10; LH was high or high-normal in 5/10; testosterone was decreased in one.
Final height in nine cases ranged from −1.57 to 0.80 SDS.
All had spontaneous puberty; only one needed androgen therapy.
Conclusions.
There is good prognosis for growth and spontaneous pubertal development but not for fertility.
Though additional studies are required, screening for learning disabilities is advisable.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gabriel Ribeiro de Andrade, Juliana& Marques-de-Faria, Antonia Paula& Fabbri, Helena Campos& de Mello, Maricilda Palandi& Guerra-Junior, Gil& Maciel-Guerra, Andréa Trevas. 2014. Long-Term Follow-Up of Patients with 46,XY Partial Gonadal Dysgenesis Reared as Males. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036500
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gabriel Ribeiro de Andrade, Juliana…[et al.]. Long-Term Follow-Up of Patients with 46,XY Partial Gonadal Dysgenesis Reared as Males. International Journal of Endocrinology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1036500
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gabriel Ribeiro de Andrade, Juliana& Marques-de-Faria, Antonia Paula& Fabbri, Helena Campos& de Mello, Maricilda Palandi& Guerra-Junior, Gil& Maciel-Guerra, Andréa Trevas. Long-Term Follow-Up of Patients with 46,XY Partial Gonadal Dysgenesis Reared as Males. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036500
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036500
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر